硫酸镁对异氟烷催眠、镇痛作用的影响

Effects of magnesium sulfate on the hypnotic and analgesic functions of isoflurane

目的 观察硫酸镁对异氟烷催眠、镇痛作用的影响.方法 将小鼠随机分为硫酸镁（MgSO4）组、异氟烷（ISO）组、硫酸镁＋异氟烷（MgSQ＋ ISO）组.利用翻正反射实验,记录各组小鼠的入睡率;利用甩尾实验测定各组小鼠用药前后的甩尾潜伏期（tail-flick latency,TFL）.结果 在翻正反射实验中,MgSQ＋ISO组与ISO组相比,小鼠的入睡率虽提高但差异无统计学意义（P＞0.05）.在甩尾实验中,与基础痛阈相比,给药后10 min MgSO4＋ISO组小鼠TFL延长（P＜0.05）.与ISO组相比,给药后10 min MgSO4＋ ISO组小鼠TFL延长（P＜0.05）.结论 硫酸镁能否增强异氟烷的催眠作用尚待进一步研究,但能增强异氟烷的镇痛作用.

Objective To observe the effects of magnesium sulfate on the hypnotic and analgesic functions of isoflurane. Methods Mice were randomly divided into a magnesium sulfate （MgSO4） group, an isoflurane （ISO） group, and a magnesium ＋ isoflurane sulfate （ MgSO4 ＋ ISO） group （ n = 10 for each）. The sleeping rate of each group was recorded by the righting reflex test. Meanwhile, the tail - flick latency of each group was determined by the tail - flick test before and after treatment. Results In the righting reflex test, the MgSO4 ＋ ISO group presented a higher sleeping rate without statistic differences when compared with the ISO group （ P 〉 0.05 ）. Compared with the baseline, an extended TEL was detected in the MgSO4 ＋ ISO group 10 min after treatment using the tail - flick test （ P 〈 0.05 ）. Also, 10 min after treatment, the tail - flick latency was longer in the MgSO4 ＋ ISO group than the ISO group （ P 〈 0.05 ）. Conclusion Magnesium sulfate can enhance the analgesic function of isoflurane, while its influence on the hypnotic effect of isoflurane requires further investigation.