低尿酸血症与糖脂代谢的相关性分析

The relationship between hypouricemia and glucose and lipid metabolism

目的分析低尿酸血症与糖脂代谢相关性指标的关系。方法将1 241例体检者按血尿酸值分为低尿酸组和正常组,然后按性别分为男性低尿酸组、正常组和女性低尿酸组、正常组,分别对其进行糖脂代谢相关指标的检测和比较。结果低尿酸组与正常组进行比较,血糖、低密度脂蛋白、载脂蛋白A、载脂蛋白B的差异有统计学意义(P<0.05)。男性正常组、低尿酸组比较,血糖、高密度脂蛋白、低密度脂蛋白、载脂蛋白A的差异有统计学意义(P<0.05)。女性正常组和低尿酸组比较,只有血糖和载脂蛋白A的差异有统计学意义(P<0.05)。结论低尿酸血症与糖、脂代谢关系密切,尿酸异常可能是糖、脂代谢紊乱的原因或结果。

Objective To analysis the relationship between hypouricemia and glucose and lipid metabolism.Methods 1 241 indi-viduals who took healthy examination in the hospital were enrolled in the study,and were divided into 2 groups which were hypouri-cemia group and normal group by uric acid concentration.Then the groups were divided by sex,we get hypouricemia and normal group of man,hypouricemia and normal group of women.The detection and comparison of glucose and lipid metabolism related indi-cators were performed to those groups.Results When hypouricemia group compared with normal group,the serum concentrations of low-density lipoprotein,apolipoprotein A,apolipoprotein B were statistically different（P〈0.05）.While compared with the nor-mal group of men hypouricemia groupblood sugar,high-densityl ipoprotein,low density lipoprotein,apolipoprotein were statistically different（P〈0.05）.In the comparison of hypouricemia group of man with normal group of man,the serum concentrations of glu-cose,high density lipoprotein,low density lipoprotein,apolipoprotein A showed statistically difference（P〈0.05）,while in women only blood glucose and apolipoprotein A concentrations showed statistically difference（P〈0.05）.Conclusion Hypouricemia is closely related with glucose and lipid metabolism,uric acid is presumably the cause and outcome of glucose and lipid disorders.