胱抑素C水平与急性冠脉综合征患者病变程度及PCI治疗预后的关系

The relationship between serum cystatin C concentration and the severity of ACS patients with lesions degree and PCI treatment prognosis

目的：探讨急性冠状动脉综合征（ACS）患者血清胱抑素 C（Cys C）水平与冠脉病变程度和经皮肤内冠状动脉介入治疗（PCI）治疗患者预后的关系。方法选取该院诊断为 ACS 并成功接受 PCI 手术治疗的352例患者作为 ACS 组，另选取同期行冠脉造影检查结果合格的60例患者作为对照组。检测患者血脂及血清 Cys C 水平，分析其与冠脉病变支数、Gensini 评分的关系，分析 ACS 患者不同 Cys C 水平等级发生主要心血管事件的风险。结果 ACS 患者血清 Cys C 水平显著高于对照组患者（P＜0．05）。病变冠脉支数不同的 ACS 患者血清 Cys C 水平的差异均有统计学意义（P ＜0．05），支数越多的患者血清 Cys C 水平越高。ACS 患者血清 Cys C 水平与 Gensini 积分呈正相关（r＝0．84，P ＜0．05）。Cys C 高水平组患者1年内发生主要心血管事件的风险均较对照组显著增加，其 OR 值为16．63（95％CI ：3．87～71．49，P ＜0．05）。结论 Cys C 水平与冠状动脉病变程度及 PCI 治疗后1年内主要心血管事件的发生有关。

Objective To explore the relationship between serum cystatin C concentration and severity of coronary artery disease and prognosis after peripheval component interconnet（PCI）treatment.Methods 352 patients diagnosed as ACS and received PCI treatment successfully were enrolled in the study as ACS group.In addition to that,60 people who underwent coronary angiography and the test results was good were recruited as control group.The serum lipids,cystatin C concentrations were tested,and the rela-tionship between the number of coronary lesions,Gensini score and cystatin C concentrations were analyzed.The risks of major car-diovascular events in different cystatin C concentration groups were analyzed.Results Cystatin C concentrations of ACS group were significant higher than control group （P 〈0.05）.Cystatin C concentrations were significantly different among patients with different number of diseased branches（P 〈0.05）.The patients with higher number of diseased branches were with higher concen-tration of cystatin C.There was a positive correlation between cystatin C concentration and Gensini score （r=0.84,P 〈0.05）.The risk of major cardiovascular events in high cystatin C concentration group within 1 year after PCI treatment increased significantly compared with control group,the OR values were 16.63（95%CI ：3.87-71.49,P 〈0.05）.Conclusion Cystatin C correlated with the severity of coronary artery disease and the occurrence of major cardiovascular events within one year after PCI treatment.