42例新生儿无乳链球菌败血症耐药性分析

Antimicrobial resistance in 42 cases of neonate septicemia caused by Streptococcus agalactiae infection

目的了解该院住院新生儿无乳链球菌败血症的临床特点及无乳链球菌的耐药性,为临床用药提供参考。方法采用VITEK-2全自动微生物分析鉴定系统和临床实验室标准化协会(CLSI)2012年的判断标准,对该院临床分离的42株无乳链球菌的来源科室分布和药敏试验情况进行统计分析。结果早产新生儿监护病房3例、足月新生儿监护病房26例、儿童重症监护病房7例、极早产新生儿监护病房6例;无乳链球菌对氨苄西林、红霉素、克林霉素、喹努普汀/达福普汀、利奈唑烷、青霉素、四环素、替加环素、万古霉素、左氧氟沙星的耐药率分别为0.0%、69.0%、71.4%、0.0%、0.0%、0.0%、74.4%、0.0%、0.0%和38.1%。结论该院新生儿血流感染无乳链球菌对多种抗菌药物的耐药率较高,建议临床首选氨苄西林、青霉素,合理选用抗菌药物进行治疗。

Objective To investigate clinical features and drug resistance of neonate septicemia caused by Streptococcus agalac-tiae in the hospital and to provide clinical guidance for treatment.Methods 42 Streptococcus agalactiae isolates in the hospital were identified and their department distribution as well as drug susceptibility was determined by using automatic VITEK-2 system and criteria released by CLSI in 2012.Results The number of cases in preterm neonatal intensive care unit,full-term neonatal intensive care unit,pediatric intensive care unit and extremely preterm neonatal intensive care unit were 3,26,7 and 6,respectively.The drug resistance rates of the isolated Streptococcus agalactiae to ampicillin,erythromycin,clindamycin,quinupristin/dalfopristin,linezolid, penicillin,tetracycline,tigecycline,vancomycin and levofloxacin were 0.0%,69.0%,71.4%,0.0%,0.0%,0.0%,74.4%,0.0%, 0.0% and 38.1%,respectively.Conclusion The antimicrobial resistance rates of Streptococcus agalactiae which caused neonatal septicemia in our hospital are relatively high.Ampicillin and penicillin are recomended in treatment for neonate septicemia caused by Streptococcus agalactiae .