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多环芳烃的致癌性机制研究进展 被引量:9

Mechanism research progress of carcinogenicity of polycyclic aromatic hydrocarbon(PAH)
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摘要 多环芳烃是一类被国际社会特别关注的持久性有机污染物,是最早被发现的具有"三致作用"的环境污染物之一。其广泛存在于多种环境介质中,虽然量少,但不断地生成、迁移、转化和降解,并通过呼吸道、消化道、皮肤等途径进入人体,极大地威胁着人类的健康。 Polycyclic aromatic hydrocarbon is a persistent organic pollutant that has been specially concerned by international community, it is one of the earliest found environmental pollutants with three-inducing impact.It widely exists in various environmental media although the number is small, but with continuous generation, migration, transformation and degradation, it"enters human body through the ways such as respiratory tract, digestive tract, and skin, which greatly threatens human health.
出处 《中国疗养医学》 2014年第9期787-789,共3页 Chinese Journal of Convalescent Medicine
基金 内蒙古教育厅项目(NJZZ12214) 内蒙古自然科学基金(2012MS1108)
关键词 多环芳烃 致癌性 机制 Polycyclic aromatic hydrocarbon Carcinogenicity Mechanism
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参考文献24

  • 1Huc L, Rissel M, Solhaug A, et al. Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-ex- posed heparic F258 cells[J].J Cell Physiol, 2006,208 (3): 527-537.
  • 2Kim SJ, Ko CB, Park C, et al.p38 MAP kinase regulates benzo(a)pyrene-induced apoptosis through the regulation of p53 activation [J ]. Arch Biochem Biophys, 2005,444 (2) : 121-129.
  • 3龙耀庭.生物大分子(DNA及蛋白质)加和物的质谱分析鉴别[J].环境科学,1995,16(6):79-82. 被引量:3
  • 4Li D, Firozi PE, Wang LE, et al. Sensitivity to DNA dam- age induced by benzo(a)pyrene diol epoxide and risk of lung cancer : a case-control analysis[J]. Cancer Research, 2001 , 6(4) : 1445-1450.
  • 5Herman A.Genetic polymorphisms in human xenobiotica me- tabolizing enzymes as susceptibility factors in toxic response [ J ]. Mutat Res, 2000,464 ( 1 ) : 65-76.
  • 6Lee CY, Lee JY, Kang JW, et al. Effects of genetic poly- morphisms of CYP1A1 , CYP2E1 , GSTM1, and GSTY1 on the urinary levels of 1-hydroxypyrene and 2-naphthol in aircraft maintenance workers[J].Toxical Lett, 2001,123(2-3) : 115-124.
  • 7Murray GI, Melvin WT, Greenlee WF, et al. Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1 [J]. Annu Rev Pharmacol Toxicoh, 2001 (41) : 297-316.
  • 8Murray GI, Taylor MC , McFadyen MC, et al. Tumor-specific expression of cytoehrome P450 CYP1B1 [J].Caneer Res, 1997, 57 ( 14 ) : 3026-3031.
  • 9Helzlsouer KJ, Selmin O, Huang HY, et al. Association be- tween glutathione S-transferase M1 , P1 and T1 genetic polymorphisms and development of breast cancer[J]. J Natl Cancer Inst , 1998 , 90(70) : 512-518.
  • 10Pavanello S, Clonfero E.Biological indicators of genotoxic risk and metabolic polymorphisms[J]. Mutat Res, 2000,463 ( 3 ) : 285-308.

二级参考文献40

  • 1龙耀庭.有毒化学物质对DNA的损伤——生成DNA加成物[J].环境科学进展,1993,1(4):24-40. 被引量:11
  • 2Mastrangelo G,Fadda E,Marzia V.Polycyclic aromatic hydr-ocarbons and cancer in man[J].Environ Health Perspect,1996,104(11):1166-1170.
  • 3Alexandrov K,Rojas M,Rolando C.DNA damage by benzo (a)pyrene in human cells is increased by cigarette smoke and decreased by a filter containing rosemary extract,which lowers free radicals[J].Cancer Res,2006,66(24):11938-11945.
  • 4Vogelstein B,Lane D,Levine AJ.Surfing the p53 network[J].Nature,2000,408(6810):307-310.
  • 5Levrero M,De Laurenzi V,Costanzo A,et al.The p53/p63/p73 family of transcription factors:overlapping and distinct functions[J].J Cell Sci,2000,113(Pt10):1661-1670.
  • 6Michael D,Oren M.The p53 and Mdm2 families in cancer[J].Curt Opin Genet Dev,2002.12(1):53-59.
  • 7Zeng X,Chen L,Jost CA,et al.MDM2 suppresses p73 function without promoting p73 degradation[J].Mol Cell Biol,1999,19(5):3257-3266.
  • 8Calabro V,Mansueto G,Parisi T,et al.The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63[J].J Biol Chem,2002,277(4):2674-2681.
  • 9Mosmann T.Rapid colorimetric assay for cellular growth and survival:application to proliferation and cytotoxicity assays[J].J Immunol Methods,1983,65(1-2):55-63.
  • 10Livak l(J,Schmittgen TD.Analysis of relative gene expression data using real-time quantitative PCR and the 2[-Delta Delta C (T)][J].Methods,2001,25(4):402-408.

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