血清Ⅲ型前胶原测定在肝纤维化诊断中的应用

Application of serum procollagen type Ⅲ measurement to hepatic fibrosis diagnosis

目的分析血清Ⅲ型前胶原(PCⅢ)的测定在肝纤维化诊断中的应用价值。方法选取121例处于不同炎症进展期的病毒性肝炎患者的标本,采用放射免疫法(RIA)测定血清中的PCⅢ水平,比较各组肝病患者之间及健康献血者血清PCⅢ差异,结合病理结果进行分析。结果血清PCⅢ水平在肝炎各组及肝硬化不同病理分期的差异均有统计学意义(P<0.05),在慢性肝炎中度患者明显升高,以慢性肝炎重度、肝硬化者为最高,其升高程度与肝纤维化及肝病严重程度呈正相关。结论血清PCⅢ水平与肝纤维化程度相关,可作为反映慢性肝病肝纤维化严重程度的指标。

Objective To explore the application value of serum procollagen type m （PC Ⅲ ）measurement in hepatic fibrosis diagnosis. Methods 121 sufferers with viral hepatitis in different progressive stages were selected to be the samples,and PCⅢ levels were measured by radioimmunoassay（RIA）, then compared the differences of PC Ⅲ in serum of liver disease sufferers and in healthy blood donors, and the data were analyzed with pathological results. Results The differences of serum PC Ⅲ levels in sufferers with hepatitis and liver cirrhosis in pathological stages were of statistical significance （P 〈 0.05）.Serum PC Ⅲ levels clearly rose in sufferers with moderate chronic hepatitis, with the highest in sufferers with severe chronic hepatitis and liver cirrhosis.The increased degree was positively related to the degree of hepatic fibrosis and severity of liver diseases.Conclusion Serum PC Ⅲlevels are related to the degree of hepatic fibrosis,which can be taken as an index to reflect the severity level of hepatic fibrosis in chronic liver diseases.