摘要
目的探讨臂踝脉搏波传导速度(baPWV)、Rho相关的卷曲蛋白激酶(ROCK)活性同冠心病的关系。方法根据冠脉造影结果将168例入选人群分为冠心病组(123例)和非冠心病组(45例),测定baPWV、ROCK活性。其中冠心病组根据主要血管病变支数不同,分为单支、双支和多支病变组。结果冠心病组的baPWV、ROCK活性高于非冠心病组(P<0.05),冠脉病变支数越多,baPWV值越高(P<0.05)。结论 baPWV、ROCK活性与冠心病相关。二者联合可用于预测及评估冠心病及其危险程度。
Objective To determine the relationship between brachial-ankle pulse wave velocity（baPWV）and Rho associated coiled coil protein kinase（ROCK）activity with the cardiovascular disease（CVD）.Methods 168 patients with CVD were divided in-to the CVD group（123 cases）and the non-CVD group（45 cases）based on the results of coronary angiography.The baPWV value and the ROCK activity were detected.The CVD group were subdivided into the single vessel,double vessels and multiple vessels le-sions groups.Results The baPWV value and ROCK activity in the CVD group were significantly higher than those in the non-CVD group（P〈0.05）.The more the lesion vessels,the higher the baPWV value（P〈0.05）.Conclusion The baPWV and ROCK activi-ty are associated with CVD.Therefore,the combined measurement of baPWV and ROCK levels could be used to assess CVD and its risk degree.
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第25期3287-3289,3292,共4页
Chongqing medicine
