布拖县102例艾滋病患者抗病毒治疗效果分析

Effect analysis of antiviral treatment in 102 cases of AIDS in Butuo county

目的了解当地艾滋病(AIDS)患者高效抗逆转录病毒治疗(HAART)效果,分析影响治疗效果的因素,提高抗病毒治疗质量。方法定期随访监测HAART患者CD4T淋巴细胞,观察抗病毒治疗效果。结果在24个月随访监测期中,102例抗病毒治疗患者CD4T淋巴细胞计数逐步增加,前3个月增加较明显(P<0.01),吸毒患者和性传患者CD4T淋巴细胞计数组内比较差异无统计学意义(P>0.05),11例病死患者CD4T淋巴细胞基线均数小于200个/μL,治疗3个月后CD4T淋巴细胞计数较基线差异无统计学意义(P>0.05)。结论该群AIDS患者HAART的免疫学疗效不理想。

Objective To understand the effect of the highly active antiretroviral therapy（HAART）in the local AIDS patients and to analyzes the factors affecting the treatment effect for improving the quality of antiviral therapy.Methods The CD4 T lym-phocyte count in the patients with HAART was regularly followed-up and monitored,and the antiviral treatment effect was ob-served.Results During 24-month follow-up monitoring period,the CD4 T lymphocyte count in 102 cases of HAART was gradually increased,the increase during the first 3 months was more obvious（P〈0.01）,the intra-group comparison showed that CD4 T lym-phocyte count in the drug-taking patients and the sexually transmitted patients had no statistical difference（P〉0.05）,the baseline mean of CD4 T lymphocyte count from 11 dead patients was less than 200/μL,but the CD4 T lymphocyte count after 3-month treatment had no statistical difference compared with the baseline mean（P〉0.05）.Conclusion The immunological effect of HAAR in the group AIDS patients is poor.