痛风性关节炎与高尿酸血症炎性细胞因子水平比较

Comparison of Inflammatory Cytokines Level between Gouty Arthritis and Hyperuricemia

目的:观察痛风性关节炎和高尿酸血症患者肿瘤坏死因子α(TNF-α)、白细胞介素-1(IL-1)和白细胞介素-6(IL-6)等炎性细胞因子的血清水平。方法:分别测定41例痛风性关节炎患者(痛风组)、52例高尿酸血症患者(高尿酸组)和30例健康体检者(对照组)3组人群TNF-α、IL-1和IL-6等细胞因子血清水平。结果:TNF-α、IL-1和IL-6痛风组明显高于高尿酸组、对照组(P<0.05)。TNF-α、IL-1高尿酸组与对照组无明显差异(P>0.05),IL-6高尿酸组高于对照组(P<0.05)。结论:炎性细胞因子在痛风性关节炎患者的发病过程中起到了重要作用,而无症状的高尿酸血症患者炎性细胞因子还未达到导致炎症的水平。

Objective： To observe the levels of inflammatory cytokines including tumor necrosis factor α（TNF-α）, interleukin-1 （IL-1）, interleukin-6 （IL-6） and others of the patients with gouty arthritis and hyperuricemia. Methods：The levels of TNF-α, IL-1 and IL-6 in 41 patients with gouty arthritis （gout group）, 52 ones with hyper-uricemia （hyperuricemia group） and 30 ones who underwent health examination （the control group） were respective-ly detected. Results：Gout group was significantly higher than hyperuricemia group and the control group in the lev-els of TNF-α, IL-1 and IL-6 （P〈0.05）. There was insignificant difference in the levels of TNF-αand IL-1 between hyperuricemia group and the control group （P〉0.05）, hyperuricemia group was higher than the control group in the level of IL-6 （P〈0.05）. Conclusion：Inflammatory cytokines play an important role in the onset of gouty arthritis, whreas inflammatory cytokines haven＆#39;t been to the levels inducing the inflammation.