自体干细胞移植术后糖尿病视网膜病变的变化分析

Clinical observation of diabetic retinopathy after transplantation of autologous stem cell in diabetic patients

目的：观察自体干细胞移植术后糖尿病视网膜病变变化情况。方法：自体干细胞移植术后糖尿病患者58例116眼经直接或间接检眼镜及眼底荧光血管造影（FFA）确定为无糖尿病视网膜病变者18眼,轻度非增殖期糖尿病视网膜病变（轻度NPDR）41眼,中度非增殖期糖尿病视网膜病变（中度NPDR）51眼,重度非增殖期糖尿病视网膜病变（重度NPDR）6眼,随访6～12mo,观察视网膜病变变化情况。结果：患者视力、视网膜病变治疗的总有效率为84.4%、76.7%,其中重度非增殖期糖尿病视网膜病变组视力及视网膜病变治疗的有效率均显著低于轻、中度非增殖期糖尿病视网膜病变组及无视网膜病变组,差异有显著统计学意义（P〈0.05）。结论：自体干细胞移植术后稳定的血糖水平及胰岛功能的改善可能有助于稳定或延缓视网膜病变进展,其长期效果有待进一步深入研究。

AIM： To observe the effect of autologous stem cell transplantation in diabetic retinopathy.METHODS： Totally 58 cases（ 116 eyes） who underwent autologous stem cell transplantation were confirmed as no diabetic retinopathy（ 18 eyes）,mild non-proliferative diabetic retinopathy（ NPDR）（ 41 eyes）,mid-level NPDR（ 51 eyes）; severe NPDR（ 6 eyes） by ophthalmoscope directly or indirectly and fluorescence fundus angiography（ FFA）. Follow- up was 6- 12 mo, the changes of retinopathy were observed.RESULTS： The total effective rate of vision and retinopathy was 84.4%,76.7%. The results of severe NPDR was statistically worse than the other groups（ P〈0. 05）. CONCLUSION： The stable blood glucose level and improved pancreatic function after autologous stem cell transplantation might be helpful in diabetic retinopathy,the long effects need to be researched further.