左氧氟沙星治疗重症细菌性眼病的疗效及耐药性

Analysis of curative effect and drug tolerance in the treatment of severe bacterial oculopathy by levofloxacin

目的:研究左氧氟沙星治疗重症细菌性角膜炎和结膜炎的疗效以及耐药性。方法:将我院收治的195例重症细菌性角膜炎和结膜炎患者作为观察对象,随机均分为A组、B组和C组,分别给予左氧氟沙星、氧氟沙星和氯霉素进行治疗,统计治疗数据,评价不同治疗方法治疗的效果和耐药性。结果:采用左氧氟沙星治疗的A组患者痊愈54例(83.1%),显效7例(10.8%),有效3例(4.6%),无效1例(1.5%);采用氧氟沙星治疗的B组患者痊愈25例(38.5%),显效6例(9.2%),有效23例(35.4%),无效11例(16.9%);采用氯霉素治疗的C组患者痊愈4例(6.2%),显效3例(4.6%),有效36例(55.4%),无效22例(33.8%),组间治疗效果和耐药性存在显著差异(P<0.05)。结论:左氧氟沙星治疗重症细菌性结膜炎和角膜炎起效快,效果好,不易产生抗药性,值得推广借鉴。

AIM： To evaluate the curative effect and drug tolerance in the treatment of severe bacterial keratitis and conjunctivitis by levofloxacin.METHODS： Totally 195 patients with severe bacterial keratitis and conjunctivitis were included in this study.Based on the sequence of enrollment, they were randomly divided into three groups： group A（ 65patients） received levofloxacin,group B（ 65 patients）received suture method under microscope, group C received suture method with loupe besides the same basic operative treatment in the two groups. The curative effect and drug tolerance were observed and compared statistically.RESULTS： In group A,54 cases were cured,in the rate of 83.1%,7 cases（ 10.8%） were excellent,3 cases（ 4. 6%）were valid,1 case（ 1. 5%） was invalid. In group B,25cases（ 38. 5%） were cured, 6 cases（ 9. 2%） were excellent,23 cases（ 35.4%） were valid,11 cases（ 16.9%）were invalid. In group C,4 cases（ 6.2%） were cured,3cases（ 4. 6%） were excellent,36 cases（ 55. 4%） were valid,22 cases（ 33.8%） were invalid. The curative effect and drug tolerance among groups had obvious differences（ P〈0.05）.CONCLUSION： Levofloxaoin is effective and safe for the treatment of bacterial conjunctivitis and keratitis,which is not resistant and worthy of promotion.