三联组氨酸核苷酸结合蛋白1与人类疾病

Histidine Triad Nucleotide-binding Protein 1 and Human Diseases

三联组氨酸核苷酸结合蛋白1(HINT1)是三联组氨酸蛋白超家族成员之一,三联组氨酸因为具有保守的核苷酸结合基序组氨酸-x-组氨酸-x-组氨酸-xx(x代表1个疏水氨基酸)而得名,HINT1广泛参与肿瘤、神经精神疾病等人类疾病的病理生理过程。本文主要综述HINT1的结构、分布、酶活性基本功能,以及与人类疾病的关联。

Histidine triad nucleotide-binding protein 1 （HINT1） is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx,in which x represents hydrophobic amino acid.HINT1 is implicated in pathological progress of many human diseases including cancer and schizophrenia; however,little is known about the essential role and pathological consequences of HINT1 in cellular physiology and diseases.Therefore,we summarize the structure,distribution,and physiological function of HINT1 in cells and tissues as well as the correlation between HINT1 and human diseases.