针对谷氨酸能系统的抗抑郁药物的研究进展

Research progress of the antidepressants targeting the glutamate receptors

抑郁症是一种常见的神经精神类疾病。目前关于抑郁症的基础研究和临床治疗主要针对单胺能神经系统。但是,越来越多的证据显示,谷氨酸能系统在抑郁症的病理生理过程中发挥着非常关键的作用。该文将围绕谷氨酸能系统,综述抗抑郁药的研究现状,同时也将讨论未来抗抑郁药物的研究方向。

Depression is a worldwide neuropsychiatric disorder. Currently most preclinical and clinical studies of depression focus on monoaminergic system. However, there is growing evidence which suggests that glutamatergic system plays a critical role in the pathophysiology of depression. This review focuses on the de-velopment of new antidepressants that target glutamatergic sys-tem, summarizes the current mechanisms of antidepressants, and also highlights new insights to the pathophysiology of depression.