非哺乳期乳腺炎的免疫学研究进展

Immunological studies about the progress of non-lactating mastitis

乳腺慢性炎症是一种临床上较少见的乳腺炎性疾病,又称非哺乳期乳腺炎,近几年发病率有明显上升趋势。但由于临床医生对该病认识不足,且病因不明,从而导致目前对该病的检出率低,治愈率低。目前认为非哺乳期乳腺炎是一个免疫相关性疾病,有多种细胞及细胞因子参与疾病的发生、发展过程。各类细胞因子在非哺乳期乳腺炎的疾病进展的不同阶段,其血浆含量不同,并有一定规律。本文就肿瘤坏死因子-α,NK细胞,干扰素-γ,CD4+T细胞亚群,树突状细胞及趋化因子与非哺乳期乳腺炎之间的关系进行综述。

Chronic inflammation of the mammary gland ,also known as non -lactating mastitis, is a rare kind of clinical mastitis disease ,the incidence of which is on the rise in recent years .Due to the cause is unknown , the detected rate and cure rate are at low levels .Now think of nonpuerperal mastitis is a related immune diseases , has a variety of cells and cyto-kines involved in the occurrence and development of disease process .All kinds of cytokines in nonpuerperal mastitis of the various stages of disease progression , different levels of plasma , and has certain regularity .In this paper , the tumor necrosis factor alpha, NK cells, interferon-gamma, CD4 ＋T cells, dendritic cells and chemokines , and summarized the relation-ship between nonpuerperal mastitis .