阿立哌唑口崩片治疗精神分裂症的有效性Meta分析

Efficacy of Brisking for Schizophrenia: A Meta analyses

目的评价阿立哌唑口崩片的有效性,为其有效使用提供借鉴。方法检索CBM、CKNI数据库,时间不限。纳入随机、半随机及临床对照试验。按Cochrane 5.0版质量评价标准评价研究质量和提取数据进行Meta分析。结果共纳入7个研究。Meta分析显示:阿立哌唑口崩片与其他非经典抗精神病药物间疗效的差异无显著性意义[RR=1.01,95%CI(0.93,1.10),P=0.77];阿立哌唑口崩片与经典抗精神病药物间疗效的差异无显著性意义[RR=1.02,95%CI(0.95,1.09),P=0.68]。结论阿立哌唑口崩片对精神分裂症的阳性、阴性症状均有明显疗效,且副作用低,值得推广。

Objective To systematicly evaluate the efficacy of Brisking treating Schizophrenia , providing reference for the reasonable use of this drug .Methods We searched CBM , CNKI for randomized controlled trials （ RCTs） and quasi-ran-domization controlled trials .Quality assessment and data extraction were conducted by two reviewers independently .Meta-analyses were conducted with the Cochrane Collaboration ’ s RevMan 5.0 software.Results Seven trials met the inclusion criteria.Results Showed：The effects for Schizophrenia are no significant difference between brisking and other non -clas-sical antipsychotics[RR=1.01,95%CI（0.93,1.10）,P=0.77].The effects for Schizophrenia are also no significant difference between Brisking and classical -antipsychotics [RR=1.02,95%CI（0.95,1.09）,P=0.68].Conclusion No significant differences were observed in the effects between brisking and other antipsychotics for Schizophrenia , We could expand its use ,especially for incipient patients and elderly patients .