口服骨化三醇对喘息性支气管炎患儿血清中IgE、IL-12水平的影响

Effects of oral administration of calcitriol on serum IgE、IL-17 level in children with asthmatic bronchitis

目的通过监测口服骨化三醇的喘息性支气管炎患儿血清中IgE、IL-12水平,了解补充维生素D对喘息性支气管炎患儿的辅助治疗作用。方法喘息性支气管炎组(简称喘支组)36例,肺炎组33例,健康对照组28例,监测口服应用骨化三醇4周前后血清IgE、IL-12水平。结果口服骨化三醇前,三组血清IgE水平比较结果为:喘支组明显高于肺炎组、对照组,肺炎组与对照组比较无统计学差异;IL-12水平比较结果为:喘支组明显低于肺炎组、对照组,肺炎组与对照组比较无统计学差异。口服4周后,IgE水平:喘支组明显低于肺炎组、对照组,后两组无统计学差异;IL-12水平:喘支组明显高于肺炎组、对照组,后两组无统计学差异。结论骨化三醇可能通过调节IgE、IL-12水平达到对喘息性支气管炎的一定治疗作用。

Objective Monitoring the level of IgE、IL-12 in serum who oral calcitriol to understand the role of adjuvant therapy of vitamin D supplementation on the asthmatic bronchitis children.MethodsAsthmatic bronchitis group 36 cases, pneumonia group 33 cases, control group 28 cases, monitoring serum IgE IL-12 level before and after 4 weeks through oral application of calcitriol.Results Before oral calcitriol ,the level of serum IgE between the three groups were： asthmatic bronchitis group was significantly higher than that of the pneumonia group, control group, there were no statistical differences in pneumonia group and control group; The level of IL-12 was： asthmatic bronchitis group was significantly lower than the pneumonia group, control group, pneumonia group and the control group showed no statistical differences. The level of IgE after 4 weeks of oral calcitriol： asthmatic bronchitis group was significantly lower than the pneumonia group and the control group, the two groups showed no statistical difference; the level of IL-12： asthmatic bronchitis group was significantly higher than that of the pneumonia group, control group.ConclusionCalcitriol may down-regulation of IgE, IL-12 level reached a certain therapeutic effect on asthmatic bronchitis.