降钙素原、C-反应蛋白在儿童急性呼吸道感染中的应用价值

Clinical value of procalcitonin and C-reactive protein in children patients with acute respiratory infection

目的探讨降钙素原(PCT)和C-反应蛋白(CRP)在儿童急性呼吸道感染中的应用价值。方法分别检测458例入院就诊时和经72 h治疗后患儿的PCT和CRP水平,以30例健康体检儿童作正常对照。结果入院就诊时PCT、CRP的水平,单纯细菌感染组和病毒合并细菌感染组要显著高于单纯病毒感染组和正常对照组(P<0.05),病毒感染组和健康对照组差异无统计学意义(P>0.05),但是单纯细菌感染组PCT水平要显著高于病毒合并细菌感染组(P<0.05),而CRP的水平二者差异无统计学意义(P>0.05)。单纯细菌感染组和病毒合并细菌感染组的PCT阳性率显著高于CRP阳性率(P<0.05)。病毒感染组的CRP水平显著高于正常对照组(P<0.05),病毒感染组的PCT水平与正常对照组差异无统计学意义(P>0.05)。经72 h治疗后,单纯细菌感染组和病毒合并细菌感染组的PCT、CRP水平都较入院就诊时显著降低(P<0.05)。结论 PCT和CRP在儿童急性呼吸道感染中都显著性增高,但是在早期判定感染性质上PCT的价值要优于CRP的价值,从而能更好地指导合理用药。

Objective To investigate the application value of procalcitonin（PCT） and C -reactive protein（CRP） in acute re- spiratory infection of children. Methods Four hundred and fifty - eight patients were selected to detect the levels of PCT and CRP at the time of hospital admission and after treatment for 72 h. Furthermore, 30 healthy children were selected as normal controls. Results The levels of PCT and CRP in simple bacterial infection group and viral and bacterial co - infection group were significantly higher than those in simple herpes virus infection group and normal control group （ P 〈 0.05 ）, and there was no significant difference between viral infection group and healthy control group（P 〉0.05）. The PCT level in pure bacterial in- fection group was significantly higher than that in virus combining with bacterial infection group （ P 〈 0.05 ） , but there was no significant difference in ClIP level between the two groups（ P 〉 0.05 ）. The positive rates of PCT in bacterial infection group and virus combining with bacterial infection group were significantly higher than those of CRP（ P 〈 0.05 ）. The level of CRP in virus infection group was significantly higher than that in normal control group （ P 〈 0.05 ）, but the PCT level had no significant differ- enee between the two groups（P 〉0.05）. After 72 h treatment, both the levels of PCT and CRP decreased in pure bacterial in- fection group and virus combining with bacterial infection group（ P 〈 0.05 ）. Conclusion Both PCT and CRP levels increased significantly in children with acute respiratory tract infection, but PCT was superior to CRP in early diagnosis of the infection, which can better guide the rational use of drugs.