急性脑梗死患者血清同型半胱氨酸溶血磷脂酸B型钠尿肽的检测及临床意义

Detection and clinical significance of serum homocysteine,lysophosphatidic acid and BNP in acute cerebral infarction patients

目的动态监测急性脑梗死患者血清同型半胱氨酸(Hcy)、溶血磷脂酸(LPA)和B型钠尿肽(BNP)水平的变化。方法将74例急性脑梗死患者分为3组,轻型组、中型组、重型组,监测不同时间段<12 h、24 h、3 d、7 d、14 d Hcy、LPA、BNP的水平并进行比较分析。结果 3组脑梗死患者12 h内Hcy、LPA、BNP水平均升高,与对照组比较差异有统计学意义(P<0.05);随后3组脑梗死患者Hcy、LPA、BNP的水平达到峰值后均持续下降,而重型组14 d后仍保持较高的水平。结论动态监测有助于协助临床早治疗和早期判断急性脑梗死患者病情的严重程度。

Objective To dynamically monitor the changes of serum homocysteine （Hcy）, lysophosphatidic acid （LPA） and BNP in patients with acute cerebral infarction（ACI）. Methods Seventy - four AC! patients were divided into mild group, moderate group and severe group. The levels of Hcy, LPA and BNP were monitored in the 74 ACI cases at different time after hospital admission, 12 h, 24 h, 3 d, 7d and 14 d, and the monitoring results were compared and analyzed. Results In the three groups of ACI patients, the levels of Hcy, LPA and BNP all increased within 12 h, and the difference had statistical sig- nificance when compared to the control group（ P 〈 0.05 ）. The levels of above indices declined consecutively after reaching the peak in the three groups, but kept a high level in patients of the severe group 14 d after hospital admission. Conclusion Dy- namic monitoring of Hcy, LPA and BNP in ACI patients contributed to early judge the severity of ACI and conduct timely clini- cal treatment.