sB7-H3联合NSE对肺癌诊断的探讨

Clinical significance of sB7- H3 and NSE for diagnosing the lung cancer

目的探讨血清中sB7-H3和NSE对肺癌的应用价值。方法采收集68例肺癌患者、75例肺部良性病和65例健康对照者的血清,分别检测sB7-H3和NSE,统计诊断效能,分析sB7-H3和NSE与TMN分期的关系。结果肺癌组的sB7-H3和NSE阳性率显著高于肺部良性病组和健康对照组(P<0.05),而肺部良性病组和健康对照组差异无统计学意义(P>0.05)。sB7-H3诊断肺癌患者的敏感度(61.76%)高于NSE(51.47%)(P<0.05),sB7-H3特异度(92.86%)与NSE(94.29%)相当(P>0.05)。两项串联检测时特异性略升至97.86%,并联检测时敏感度显著提高到79.69%。sB7-H3和NSE随着TMN分期增加而升高,除了sB7-H3的Ⅰ/Ⅱ期和Ⅲ期无差别,其余均有差异。结论sB7-H3和NSE对肺癌具有较强的诊断效能,尤其sB7-H3在早期诊断中具有十分重要意义,两项并联检测能有效避免一些漏检病例。

Objective To explore the clinical value of sB7 - H3 and NSE in diagnosing lung cancer. Methods The sB7 - H3 and NSE were detected in 68 cases of lung cancer, 75 patients with benign lung disease and 65 healthy subjects. The SPSS sta- tistical software was used for statistical analysis. The relationship of sBT-I-B and NSE levels with the clinical stages of lung cancer was analyzed. Results The positive rate of sB7 - H3 and NSE were significant higher in lung cancer than other groups （P 〈 0. 05 ）, no difference between other benign hing disease group and healthy control group. The sensitivity of sB7 - H3 （61.76%） was higher than NSE （ 51.47 ） （ P 〈 0.05 ） ; the specificity were no difference between sB7 - H3 （92.68%） and NSE（94.29% ）. The sensitivity and specificity of combined detection of the two parameters were higher than detection of only one parameter. The level of sB7 - H3 and NSE was increased respectively with the increasing of clinical stages. Conclusion The sB7 - H3 and NSE have very important significance in the diagnosis for lung cancer; combined detection of them can avoid some missing cases.