海马缺血损伤机制的研究进展

Progress in Study on Mechanism of Hippocampal Ischemia Injury

海马是脑内对缺血敏感的部位之一。海马缺血损伤后生命体学习、记忆等功能减退,最终导致神经退行性疾病的发生。海马不同部位组织对缺血损伤易感性的显著差异是脑缺血病理变化的重要特点。本文就海马缺血性损伤涉及的兴奋性氨基酸毒性、氧化应激、免疫炎症、细胞凋亡等机制的研究近况作一简要综述。

The hippocampus is one of the ischemia-sensitive parts of the brain. After hippocampal ischemic injury,the organisms＇ function,such as learning and memory,declined,and eventually led to the occurrence of neurodegenerative diseases. The significant difference of selective vulnerability in the different sectors of the hippocampus is an important feature of the pathological changes of cerebral ischemia. In this article,we make a brief summary of recent research on mechanisms of hippocampal ischemic injury,including excitatory amino acid toxicity and oxidative stress,immune inflammation,and apoptosis.