血压变异性与女性冠心病的相关分析

Correlation Analysis of Blood Pressure Variability and Female Coronary Heart Disease

目的探讨诊室血压正常的患者夜间血压负荷增加对女性冠状动脉硬化的影响。方法选择诊室血压正常的女性患者190例,每个患者进行血总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、血糖、糖化血红蛋白、体质指数、动态血压测定及冠状动脉造影检查,根据冠状动脉造影结果分为冠心病组（n=98）和对照组（n=92）。结果女性冠状动脉狭窄与夜间血压变异性（OR=1.446,95%CI 1.163-1.798）、夜间收缩压均值的升高（OR=3.630,95%CI 2.954-4.311）及夜间收缩压血压负荷（OR=1.314,95%CI 1.151-1.500）及舒张压血压负荷（OR=2.086,95%CI 1.344-3.237）的增加呈正相关（P〈0.05）。结论夜间血压变异性增大、夜间血压负荷增加与冠状动脉狭窄相关。

Aim To investigate the effect of nocturnal blood pressure load increase in female patients with nor- mal blood pressure in consulting room on coronary artery atherosclerosis. Methods 190 patients with normal blood pressure in consulting room were chosen. Blood total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, blood glucose, glycosylated hemoglobin, body mass index, ambulatory blood pressure, cor- onary angiography were measured for each patients. According to the coronary angiography results, they were divided into the coronary heart disease group （ n = 98 ） and control group （ n = 92）. Results Female coronary artery stenosis was positively correlated with blood pressure variability at night （ OR = 1. 446, 95% CI 1. 163 ± 1. 798 ）, increase of the average systolic blood pressure at night （ OR = 3. 630, 95% CI 2. 954 ± 4. 311 ）, systolic blood pressure load at night （ OR = 1. 314, 95% CI 1. 151 ± 1. 500） and diastolic blood pressure at night （ OR = 2. 086, 95% CI 1. 344 ± 3. 237） （P 〈 0. 05）. Conclusion Noctumal blood pressure variability and nighttime blood pressure are related to coronary artery stenosis.