间歇性内分泌治疗老年人晚期前列腺癌的临床疗效分析

Clinical efficacy of intermittent androgen suppression treatment of advanced prostate cancer in elderly patients

目的 探讨间歇性内分泌治疗老年晚期前列腺癌的临床治疗效果及其安全性. 方法 选取78例老年晚期前列腺癌患者为研究对象,随机分为观察组（39例）和对照组（39例）,观察组间歇性内分泌治疗;对照组持续性内分泌治疗. 结果 观察组患者内分泌治疗时间比对照组长（P＜0.001）;观察组治疗12个月后生活质量优于对照组（均P＜0.05）;观察组贫血、潮热和肝功能异常等不良反应发生率比对照组低（P＜0.05）. 结论 间歇性内分泌治疗老年晚期前列腺癌可明显推迟雄性激素非依赖时间,提高患者生活质量,减少药物用量,降低贫血、潮热和肝功能异常等不良反应发生率.

Objective To explore clinical effect and safety of intermittent androgen suppression treatment of advanced prostate cancer in elderly patients.Methods 78 patients with advanced prostate cancer were enrolled,and randomly divided into the observation group and the control group （n=39 each）.Patients in observation group were treated with intermittent androgen suppression treatment.Patients in control group were treated with persistent androgen suppression treatment.Results The time of therapy was much longer in observation group than in control group （P＜ 0.001）.Quality of life was better in observation group than in control group （P＜0.05）.The incidences of adverse reactions including anemia,fever and abnormal liver function were lower in observation group than in control group （all P＜0.05）.Conclusions Intermittent androgen suppression treatment prolongs time to androgen-independent progression,improve the quality of life,reduce drug dosage and the incidence of adverse reactions in the treatment of advanced prostate cancer in the elderly.