β连环素和表皮生长因子受体在非小细胞肺癌中表达的临床研究

The expression of β-catenin and epidermal growth factor receptor in non-small-cell lung cancer and its clinical significance

目的:探讨β连环素和表皮生长因子受体在非小细胞肺癌中的表达及其临床意义。方法:采用免疫组化法回顾性研究了58例非小细胞肺癌标本β-catenin和EGFR的表达,并分析其表达与病理类型、分化程度和淋巴结转移的关系。结果:58例肺癌标本中β-catenin强阳性表达23例（36.66％）;EGFR强阳性表达27例（46.55％）,弱阳性表达19例（32.76％）;β-catenin和EGFR的表达与病理类型均无关;β-catenin的表达与分化程度有关;β-catenin和EGFR的表达均与有无淋巴结转移密切相关;β-catenin与EGFR的表达呈负相关关系（r=-0.3317,P=0.0110）。结论:β-catenin与EGFR的表达与非小细胞肺癌的生长分化、淋巴转移等恶性行为密切相关,EGFR的高表达可能与β-catenin表达水平降低有关。

Objective: To investigate the expression of β-catenin and epidermal growth factor receptor in non-small-cell lung cancer and its clinical significance. Methods: The expression of β-catenin and epidermal growth factor receptor in 58 cases of non-small-cell lung cancer tissue sections were detected by immunohistochemistry. Correlations were investigated between fj-catenin and EGFR immunostaining in primary tumors and histological grade, lymph node stage.Results:23 of 58 cases showed strong β-catenin immunostaining and 27 of 58 cases showed strong EGFR immunostaining. β-catenin expression showed significant correlation with grades of differentiation. There were significant correlations between β-catenm and ECFR. expression and lymph node metastasis. Conclusion: The change of β-catenin and ECFR expression in surgically treated NSCLC are clearly associated with lymph node metastasis and histological grade.