短期胰岛素泵强化治疗对初诊2型糖尿病血糖指标的影响

目的分析短期胰岛素泵强化治疗对初诊2型糖尿病患者血糖指标的影响。方法将江西省吉安市中心人民医院2012年8月～2013年4月接收的、初次诊断为2型糖尿病的56例患者随机均分为观察组和对照组(n=28)。观察组给予胰岛素泵强化治疗,对照组给予常规皮下注射治疗,比较治疗前后2组患者4项血糖指标的变化。结果 2组患者治疗前空腹血糖(FBG)、餐后2h血糖值(2hPG)、糖化血红蛋白水平(HbA1c)、三酰甘油(TG)差异无统计学意义;治疗2周后,对照组患者FBG、2hPG、HbA1c、TG依次为(5.6±0.3)mmol/L、(9.8±1.2)mmol/L、(8.5±0.6)%、(1.1±0.2)mmol/L;观察组患者FBG、2hPG、HbA1c、TG依次为(10.6±0.9)mmol/L、(16.9±2.3)mmol/L、(10.7±0.3)%、(2.1±0.3)mmol/L,明显低于治疗前,差异有统计学意义(P<0.05);且与对照组治疗后比较差异亦有统计学意义(P<0.05)。结论短期胰岛素泵强化治疗可以明显降低初诊2型糖尿病患者的FBG、2hPG、TG、HbA1c,疗效良好。

Objective To analyze the effect of short-term intensive treatment with insulin pump on glycemic index of patients with newly diagnosed type 2 diabetes mellitus.Methods Fifty-six patients with diabetes mellitus treated in our hospital from August 2012 to April 2013 were randomly divided into observation group and control group. Patients of the observation group were given short-term intensive treatment with insulin pump for two weeks and the control group were given conventional subcutaneous injection. Before and after treatment, FBG, 2hPG, TG, HbA1c of two groups were compared.Results Two groups of patients before fasting blood glucose （FBG）, 2 h postprandial blood glucose values （2 HPG）, glycosylated hemoglobin （HbA1c）, three acyl glycerin （TG） there was no statistically significant difference; 2 weeks after treatment, the control group patients FBG, TG 2 HPG, HbA1c, followed by （5.6±0.3） （tendency/L）, （9.8±1.2） （tendency/L）, （8.5±0.6） %, （1.1±0.2） （tendency for L）; Observation group of patients with FBG, TG 2 HPG, HbA1c, followed by （10.6±0.9）tendency/L, （16.9±2.3） tendency/L, （10.7±0.3） %, （2.1±0.3） tendency/L, signiifcantly lower than before the treatment, the difference was statistically signiifcant （P 〈 0.05）; And compared with the control group after treatment differences are statistically signiifcant （P 〈 0.05）.Conclusion The short-term intensive treatment with insulin pump can signiifcantly reduce FBG, 2hPG, TG, HbA1c of patients with newly diagnosed type 2 diabetes mellitus, and the clinical effect is good, worthy of clinical popularization and application.