噻托溴铵联合阿奇霉素治疗老年人慢性阻塞性肺疾病的疗效及对肺功能的影响

The clinical efficacy of tiotropium bromide combined with azithromycin in the treatment of elderly patients with chronic obstructive pulmonary disease and its effects on pulmonary function

目的：探讨噻托溴铵联合阿奇霉素治疗老年人COPD的临床疗效及对肺功能的影响。方法将100例老年COPD患者采用随机数字表法分为两组，每组各50例，其中对照组给予噻托溴铵治疗，观察组采取噻托溴铵联合阿奇霉素治疗，比较两组临床疗效及肺功能各项指标变化。结果观察组治疗后Borg评分和6 min步行距离（6MWD）分别为（2．31±0．17）分和（380．13±15．07） m，均较治疗前的（3．17±0．26）分和（270．41±13．03）m及对照组的（2．84±0．25）分和（320．18±14．78）m显著改善（t＝6.84、8．56、7．90、8.73、7．79、8．21，均P＜0．05）；观察组治疗后FVC、FEV1和FEV1/FVC 分别为（2．54±0．44） L、（2．13±0．35）L和（72．38±5．61）％，均较治疗前的（1．63±0．37）L、（1．24±0．24）L和（47．30±5．48）％及对照组的（2．18±0．39）L、（1．69±0．35）L和（61．66±5．32）％显著增加（t＝6．35、7．76、7．02、8．04、7．14、7．95、6．91、7．41、7．60，均P＜0．05）。结论噻托溴铵联合阿奇霉素治疗老年COPD疗效显著，且能明显改善患者肺功能，具有较好的临床应用价值。

Objective To investigate the clinical curative effect of tiotropium bromide combined with azithro -mycin in the treatment of elderly patients with chronic obstructive pulmonary disease （ COPD） and its effect on lung function.Methods 100 senile COPD patients were randomly divided into the two groups ,50 cases in each group.The control group was given tiotropium therapy , while the observation group used tiotropium bromide combined with azithromycin.The clinical efficacy and pulmonary function indices were compared between the two groups .Results Borg score and 6min walking distance （6MWD） of the observation group after treatment were （2.31 ±0.17） points and （380.13 ±15.07）m,which were significantly better than （3.17 ±0.26）points,（270.41 ±13.03）m of before treatment and （2.84 ±0.25）points,（320.18 ±14.78）m of the control group （t=6.84,8.56,7.90,8.73,7.79, 8.21,all P〈0.05）;FVC,FEV1 and FEV1/FVC of the observation group after treatment were （2.54 ±0.44） L, （2.13 ±0.35）L and （72.38 ±5.61）%,which were significantly higher than （1.63 ±0.37）L,（1.24 ±0.24）L and （47.30 ±5.48）%before treatment and （2.18 ±0.39） L,（1.69 ±0.35） L and （61.66 ±5.32）% of the control group （t=6.35,7.76,7.02,8.04,7.14,7.95,6.91,7.41,7.60,all P〈0.05）.Conclusion Tiotropium bromide combined with azithromycin has significant curative effect in the treatment of senile COPD and can obviously improve the pulmonary function of patients ,which has good clinical application value .