摘要
藁本内酯是川芎和当归的主要有效成分,其化学结构的不稳定性限制了它的进一步研究和临床应用。本实验通过色谱方法对其室温静置一个月后的产物进行制备,得到了14个藁本内酯的转化产物,并通过ESIMS、NMR等光谱分析法确定了其结构,包括一个新化合物7'-carboxyl-wallichilide(1)。利用LC-MS峰面积归一化法,确定了藁本内酯及其转化产物的相对含量,阐明了藁本内酯的主要转化产物为其二聚体。
Ligustilide is one of main active components from Rhlzoma Chuanxiong and Radix Angelicae Sinensis. Howev- er,the instability of ligustilide limits its further research and application in clinics. In this study,the transformation prod- ucm of ligusfillde were prepared,after one month at room temperature,by conventional chromatography and spectroscopic methods. Fourteen transformation products were obtained and elucidated, which included a new dimerphthalide,namely, 7＇-carboxyl-wallichilide （ 1 ）. The relative contents of ligustilide and its fourteen transformation products were determined by area normalization using LC-MS. The results showed that ligustilide dimers were the main transformation products of ligustilide.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2014年第9期1339-1344,共6页
Natural Product Research and Development
基金
The Key Project of Chinese Ministry of Education(211060)
Research Fund for the Doctoral Program of Higher Education of China(20123107120009)
Shanghai Committee of Science and Technology,China(11ZR1434500)
Innovation Program of Shanghai Municipal Education Commission(12ZZ124)
关键词
藁本内酯
稳定性
转化产物
ligastilide
stability
transformation products
