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ω-3联合ω-6多聚不饱和脂肪酸对开颅血肿清除术患者疗效的研究 被引量:1

Effect of ω-3 combined with ω-6 polyunsaturated fatty acid in patients with craniotomy and evacuation of hematoma
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摘要 目的 观察使用ω-6多聚不饱和脂肪酸(单药组)和ω-3联合ω-6多聚不饱和脂肪酸(联合组)对开颅血肿清除术患者白细胞介素(IL)及C反应蛋.白(CRP)的影响.方法 将21例开颅血肿清除术患者随机分为单药组(n=10)和联合组(n=11).观察两组术前、用药后第3天、用药后第7天IL、CRP、住院时间等指标.结果 用药后第3天,单药组IL-6[(318.5 ±51.7) mg/L]和CRP浓度[(93.1±33.6)mg/L]较术前IL-6[(338.9 ±44.6)mg/L]和CRP浓度[(123.7 ±37.2) mg/L]显著降低(P<0.05),联合组IL-2[(650.1 ±59.3)mg/L,P<0.01]、IL-6[(286.4±34.9)mg/L,P<0.01]、IL-8[(306.4 ±44.8) mg/L,P<0.01]、IL-10[(82.8±32.1)mg/L,P<0.05]和CRP浓度[(89.2±37.1)mg/L,P<0.01]较术前显著降低;使用后第7天,单药组IL-2[(635.1 ±70.3)mg/L,P<0.01]、IL-6[(286.2 ±41.8) mg/L,P<0.01]、IL-10[(158.6±51.1)mg/L,P<0.05]和CRP浓度[(88.9±29.2) mg/L,P<0.05]较术前显著降低,联合组中IL及CRP浓度进一步降低.结论 联合使用ω-3和ω-6多聚不饱和脂肪酸可提高患者治疗效果,促进患者术后恢复及改善患者预后. Objective Comparing the effects of ω-6polyunsaturated fatty acid (Single group)and ω-3 combine ω-6 polyunsaturated fatty acid (Combine group) on interleukin (IL) and C-reactive protein (CRP) of patients with craniotomy evacuation of hematoma.Methods 21 patients were randomly assigned into Single group (n =10) and Combine croup (n =11).The index of IL and CRP of pre-operation,3 days and 7 days after administration drugs,and resident time was recorded detailed.Results After 3 days of administration drugs,concentrations of IL-6 [(318.5 ± 51.7) mg/L,P 〈 0.01] and CRP [(93.1 ±33.6) mg/L,P 〈 0.05] in single group andIL-2 [(650.1 ± 59.3) mg/L,P 〈 0.01)],IL-6 [(286.4 ±34.9) mg/L,P〈0.01)],IL-8 [(306.4±44.8) mg/L,P〈0.01)],IL-10 [(82.8±32.1) mg/L,P 〈0.05] and CRP [(89.2 ± 37.1) mg/L,P 〈 0.01)] in combine group were significantly lower than pre-operation,respectively.After 7 days of administration drugs,concentrations of IL-2 [(635.1 ±70.3) mg/L,P〈0.01)],IL-6 [(286.2 ±41.8) mg/L,P〈0.01)],IL-10 [(158.6 ±51.1) mg/L,P〈0.05)] and CRP [(88.9 ± 29.2) mg/L,P 〈 0.05)] in single group were significantly lower than pre-operation,respectively.Concentrations of ILand CRP in combine group reducedmore than 3 days after administration drugs.Conclusion Combined use of ω-3 and ω-6 polyunsaturated fatty acid may play an important role in improving the effects of treatment,recovering and prognosis of patients.
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2014年第9期1916-1918,共3页 Chinese Journal of Experimental Surgery
关键词 白细胞介素 C反应蛋白 ω-6多聚不饱和脂肪酸 ω-3多聚不饱和脂肪酸 Interleukin C-reactive protein ω-6 polyunsaturated fatty acid ω-3 polyunsaturated fatty acid
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参考文献14

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