ω-3联合ω-6多聚不饱和脂肪酸对开颅血肿清除术患者疗效的研究

Effect of ω-3 combined with ω-6 polyunsaturated fatty acid in patients with craniotomy and evacuation of hematoma

目的 观察使用ω-6多聚不饱和脂肪酸（单药组）和ω-3联合ω-6多聚不饱和脂肪酸（联合组）对开颅血肿清除术患者白细胞介素（IL）及C反应蛋.白（CRP）的影响.方法 将21例开颅血肿清除术患者随机分为单药组（n=10）和联合组（n=11）.观察两组术前、用药后第3天、用药后第7天IL、CRP、住院时间等指标.结果 用药后第3天,单药组IL-6[（318.5 ±51.7） mg/L]和CRP浓度[（93.1±33.6）mg/L]较术前IL-6[（338.9 ±44.6）mg/L]和CRP浓度[（123.7 ±37.2） mg/L]显著降低（P＜0.05）,联合组IL-2[（650.1 ±59.3）mg/L,P＜0.01]、IL-6[（286.4±34.9）mg/L,P＜0.01]、IL-8[（306.4 ±44.8） mg/L,P＜0.01]、IL-10[（82.8±32.1）mg/L,P＜0.05]和CRP浓度[（89.2±37.1）mg/L,P＜0.01]较术前显著降低;使用后第7天,单药组IL-2[（635.1 ±70.3）mg/L,P＜0.01]、IL-6[（286.2 ±41.8） mg/L,P＜0.01]、IL-10[（158.6±51.1）mg/L,P＜0.05]和CRP浓度[（88.9±29.2） mg/L,P＜0.05]较术前显著降低,联合组中IL及CRP浓度进一步降低.结论 联合使用ω-3和ω-6多聚不饱和脂肪酸可提高患者治疗效果,促进患者术后恢复及改善患者预后.

Objective Comparing the effects of ω-6polyunsaturated fatty acid （Single group）and ω-3 combine ω-6 polyunsaturated fatty acid （Combine group） on interleukin （IL） and C-reactive protein （CRP） of patients with craniotomy evacuation of hematoma.Methods 21 patients were randomly assigned into Single group （n =10） and Combine croup （n =11）.The index of IL and CRP of pre-operation,3 days and 7 days after administration drugs,and resident time was recorded detailed.Results After 3 days of administration drugs,concentrations of IL-6 [（318.5 ± 51.7） mg/L,P 〈 0.01] and CRP [（93.1 ±33.6） mg/L,P 〈 0.05] in single group andIL-2 [（650.1 ± 59.3） mg/L,P 〈 0.01）],IL-6 [（286.4 ±34.9） mg/L,P〈0.01）],IL-8 [（306.4±44.8） mg/L,P〈0.01）],IL-10 [（82.8±32.1） mg/L,P 〈0.05] and CRP [（89.2 ± 37.1） mg/L,P 〈 0.01）] in combine group were significantly lower than pre-operation,respectively.After 7 days of administration drugs,concentrations of IL-2 [（635.1 ±70.3） mg/L,P〈0.01）],IL-6 [（286.2 ±41.8） mg/L,P〈0.01）],IL-10 [（158.6 ±51.1） mg/L,P〈0.05）] and CRP [（88.9 ± 29.2） mg/L,P 〈 0.05）] in single group were significantly lower than pre-operation,respectively.Concentrations of ILand CRP in combine group reducedmore than 3 days after administration drugs.Conclusion Combined use of ω-3 and ω-6 polyunsaturated fatty acid may play an important role in improving the effects of treatment,recovering and prognosis of patients.