Eph受体酪氨酸激酶A2和SIAH2在乳腺癌中的表达及其临床意义

Expression and clinicopathologic significance of erythropoietin producing human hepatocellular receptor A2 and seven in absentia homologues 2 in breast carcinoma

目的 检测Eph受体酪氨酸激酶A2（EphA2）和SIAH2在乳腺癌组织中的表达.方法 采用免疫组织化学法检测83例乳腺癌患者手术切除的癌组织和癌旁组织中EphA2和SIAH2的表达水平,分析两者与乳腺癌临床病理特征的关系.结果 EphA2在乳腺癌组织中表达率明显高于癌旁组织（75.90％比12.05％,P＜0.01）,SIAH2在乳腺癌组织中表达率明显高于癌旁组织（67.47％比16.87％,P＜0.叭）;EphA2表达水平与乳腺癌组织学分化程度、TNM分期和淋巴结转移明显相关（P＜0.05）,SIAH2表达水平与乳腺癌肿瘤大小、TNM分期、淋巴结转移明显相关（P＜0.05）.结论 联合检测EphA2及SIAH2的表达有助于判断乳腺癌的生物学行为.

Objective To study the expression of erythropoietin producing human hepatocellular receptor A2 （EphA2） and seven in absentia homologues 2 （SIAH2） in breast carcinoma.Methods Immunohistochemical method was applied to detect the expression of EphA2 and SIAH2 in 83 cases of human breast carcinoma tissues and non-cancerous adjacent breast tissues,and the relationship with the clinicopathological factors was analyzed.Results The expression rate of EphA2 in breast carcinoma tissues was higher than that of non-cancerous adjacent breast tissues （75.90％ vs.12.05％,P ＜ 0.01）,and of SIAH2 in breast carcinoma tissues was higher than that of non-cancerous adjacent breast tissues （67.47％ vs.16.87％,P ＜0.01）.The expression of EphA2 was related to histology grade,TNM stage and lymph node metastasis of breast carcinoma （P ＜ 0.01）,and the expression of SIAH2 was related to tumor size,TNM stage and lymph node metastasis of breast carcinoma （P ＜ 0.05）.Conclusion The combined detection of EphA2 and SIAH2 may be of great value for predicting the biological behaviors of breast carcinoma.