北京儿童医院住院的腹泻患儿星状病毒感染分析

Astrovirus infection in young children hospitalized with diarrhea in Beijing Children′s Hospital

目的 了解北京儿童医院 5岁以下住院的腹泻患儿 ,星状病毒感染的临床和流行病学特点。方法 1999年 9月至 2 0 0 1年 8月 2 88例 5岁以下的住院腹泻患儿 ,每例入院后采集一份粪便标本 ,应用酶免疫法进行星状病毒和轮状病毒抗原检测 ,总结星状病毒感染腹泻患儿的病例 ,进行临床特点的分析。结果 星状病毒抗原的检出率为 9 0 % (2 6 /2 88) ,与轮状病毒的共同感染者的检出率为 1 7% (5 /2 88)。星状病毒感染患儿年龄为 7天～ 17个月 ,年龄≤ 12个月的患儿占 84 6 % ,平均年龄明显小于轮状病毒感染患儿 (5 4 5± 4 6 2个月vs 9 75± 7 83月 ,P =0 0 0 5 )。 88 5 %星状病毒感染主要集中在 10月至次年 3月 ,与轮状病毒感染季节相似。主要临床表现为腹泻、呕吐、发热、脱水 ,有4例患儿心肌酶 (乳酸脱氢酶、磷酸肌酸激酶、磷酸肌酸激酶同工酶 )升高 ,4例表现为迁延性腹泻。

Objective To understand certain epidemiological and clinical characteristics of astrovirus infection in children under 5 years of age hospitalized for diarrhea in Beijing Children′s Hospital Methods From September, 1999 to August, 2001, a total of 288 children under 5 years of age hospitalized for diarrhea in Beijing Children′s Hospital were enrolled in this study A stool specimen was collected from each patient The specimens were tested for astrovirus and rotavirus by using indirect enzyme immunoassay The data were statistically analyzed by using SPSS software The Chi square test was used to test categorical variables and t test was used to compare numerical variables All tests were considered to be significant when P <0 05 Results Astrovirus antigen was found positive in 9 0% of the patients, the coinfection rate of astrovirus and rotavirus was 1 7% (5/288) Patients with astrovirus infection were at the age of 7 days to 17 months, most of the cases (84 6%) were less than 12 months and the mean age was less than that of those infected with rotavirus significantly (5 45±4 62 months vs. 9 75±7 83 months, P =0 005) The astrovirus infections occurred mainly between October and March of the following year Main symptoms included watery stool, vomiting, fever, and dehydration; increased activity of myocardial enzyme was seen in 4 cases. Four patients had persistent diarrhea Conclusions Astrovirus may play an important role in viral diarrhea in young children in Beijing