磺胺嘧啶银联合卡泊芬净治疗烧伤创面临床观察

Clinical observation of sulfadiazine silver in combination with caspofungin in the treatment of burn wound

目的探讨磺胺嘧啶银联合卡泊芬净治疗烧伤创面临床疗效。方法 80例符合纳入标准的烧伤患者随机分为两组,每组40例。对照组给予卡泊芬净治疗,观察组在对照组的基础上联合使用磺胺嘧啶银治疗。结果观察组抗真菌感染治疗有效率为90.0%,明显高于对照组70.0%的治疗有效率(P<0.05)。观察组浅II度创面和深II度创面愈合时间分别为(8.5±2.9)d和(17.4±4.2)d,明显短于对照组的(11.9±2.5)d和(22.0±4.9)d(P<0.05)。两组患者均未出现严重的不良反应。结论磺胺嘧啶银联合卡泊芬净治疗烧伤创面疗效可靠,可以提高抗真菌感染的治疗有效率,缩短创面愈合时间,不良反应少,值得临床推广。

Objective To investigate the clinical effect of sulfadiazine silver in combination with caspofungin in the treatment of burn wound. Methods A total of 80 cases of burn patients meeting the inclusion criterions were randomly divided into two .groups, and each group contained 40 cases. The control group was treated with caspofungin, and the observation group was treated with additional sulfadiazine silver. Results The observation group had a total anti-fungal infection efficiency rate of 90.0%, which was statistically higher than 70.0% of the control group （P〈0.05）. The wound healing time of the superficial and deep second-degree burns in the observation group were （8.5 ± 2.9） d and （17.4 ± 4.2） d, which was respectively obviously shorter than （11.9± 2.5） d and （22.0± 4.9） d of the control group （P〈0.05）. There were no severe adverse reactions in the two groups. Conclusion Sulfadiazine silver in combination with caspofungin has a rehable curative effect in the treatment of burn wound, which can increase efficiency rate of anti-fungal infection, and shorten wound healing time with few adverse reactions.