除草剂吡草胺的合成

Synthesis of Metazachlor

以2,6-二甲基苯胺为原料,与多聚甲醛经亲核消除反应生成希夫碱,再与氯乙酰氯加成反应,最后与吡唑缩合转晶得到除草剂原药吡草胺三斜晶形,总收率达71.5%(以2,6-二甲基苯胺计),含量大于97%,该工艺方法简便、易行,具有工业化应用前景。

Herbicide metazachlor was synthesized from 2,6-dimethylaniline in overall yield of 71.5% （content of 97%, GC） by reactions with paraformaldehyde, chloroacetyl chloride and pyrazole.