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兰索拉唑联合生长抑素治疗急性上消化道大出血疗效观察 被引量:12

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摘要 目的观察兰索拉唑与生长抑素联合应用对急性上消化道大出血的治疗效果,探讨两者联合应用的临床价值。方法将急诊内科收治60例急性上消化道大出血患者随机分为2组,治疗组30例,对照组30例。治疗组给予兰索拉唑与生长抑素联合应用,兰索拉唑30 mg加入生理盐水100 ml静脉滴注,每天2次,生长抑素开始以250μg静脉推注,随之以250μg/h微量泵持续泵入,疗程为72 h;对照组给予兰索拉唑应用,兰索拉唑30 mg加入生理盐水100 ml静脉滴注,每天2次,疗程为72 h;连续用药72 h后分别观察治疗组与观察组止血成功例数(显效例数+有效例数)及无效例数,根据计数资料(率)及χ2检验以判定临床疗效。结果治疗组止血显效19例,有效10例,无效1例,总有效率为96.67%(29/30);对照组止血显效15例,有效7例,无效8例,总有效率为73.33%(22/30);治疗组疗效明显优于观察组,差异有统计学意义(χ2=6.444,P<0.05)。结论兰索拉唑联合生长抑素应用治疗急性上消化道大出血可明显提高止血成功率,具有良好的临床应用价值,值得临床推广应用。
作者 李文娟
出处 《中华全科医学》 2014年第11期1861-1862,共2页 Chinese Journal of General Practice
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  • 1李太一.急性上消化道出血的诊断和处理[J].中国医药指南,2008,6(22):181-183. 被引量:8
  • 2周世蓉.兰索拉唑联合铝碳酸镁治疗反流性食管炎疗效观察[J].现代医药卫生,2007,23(11):1636-1637. 被引量:3
  • 3Zvyaga T,Chang SY,Chen C ,et al. Evaluation of six proton pump inhibitors as inhibitors of various human cytochromes P450 : focus on cytochrome P450 2C19[J]. Drug Metab Dispos,2012,40(9) :1698-1711.
  • 4KuiPers EJ, Sung JJ, Barkun A, et a!. Safety and tolerability of highdose in- teravenous esomeprazole for prevention of peptic ulcer rebleeding [ J ]. Adv Ther,2011,28(2) :150-159.
  • 5Miura M, Tada H, Yasui-furukori N, et al antioselective disposition of Inasoprazole [J]. Chirality,2005,17(6) :338-344.
  • 6Effetc of clarithromycin on the en- in relation to CYP2C19 genotypes Takahashi K, Motohashi H,Yunezawa A,et al. Lansoprazole-tacrolimus interac- tion in Jpanese transplant recipient with CYP2CI9 polymorphism [J]. Ann Phar- macother ,2004,38 (5) :791-794.
  • 7Afeltra J,Vitale R G, Mouton J W, et al. Potent synergistic in vitro interaction between nonantimicrobial menbrane-active compounds and itraeonazole against elinnieal isolates of aspergillus fumigatus resistant to itraconazole[ J]. Antimi- crob Agents Chemother ,2004,48 (4) :1335-1343.
  • 8Yasui-furukori N, Saito M, Uno T, et al. Effects of fluvoxamine on Lanso- prazole pharmacokinetics in relation to CYP2C19 genotypes[ J]. J Clin phar- macol,2004,44( 11 ) : 1223-1229.
  • 9Small DS,Farid NA ,Payne CD,et al. Effects of the proton pump inhibitor lan- soprazole on the phamacokinetics and phamacodynamics of prasugrel and clo- pidogrel[ J]. J Clin Pharmacol 2008,48:475-484.
  • 10Juurlink DN,Gomes T,Ko DT,et al. A population-based study of the drug in- teraction between proton pump inhibitors and clopidogrel [ J]. CMAJ, 2009, 180:713-718.

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