丹参川芎嗪注射液中盐酸川芎嗪的大鼠排泄特征研究

Excretion of ligustrazine hydrochloride in Salviae Miltiorrhiza and Ligustrazine Hydrochloride Injection in rats

目的 研究丹参川芎嗪注射液中盐酸川芎嗪在大鼠体内的排泄特征。方法 大鼠分别静脉给予20,40,80 mg·kg^-1的丹参川芎嗪注射液,收集给药后0-4,4-8,8-12,12-24 h的尿液样品及0-2,2-4,4-6,6-12,12-24 h的胆汁样品,用HPLC方法测定浓度。结果 大鼠不同剂量静脉给予丹参川芎嗪注射液后,以原形药物经尿液和胆汁排出极少,尿液中的平均排泄量为给药剂量的1.18%,胆汁中的平均排泄量为给药剂量的0.56%。结论 盐酸川芎嗪不是以原型为主要形式从大鼠体内消除的。

Objective To study the excretion characteristics of ligustrazine hydrochloride in Salviae Miltiorrhiza and Ligustrazine Hydrochloride Injection in rats. Methods Rats were injected 20,40 and 80mg·kg^- 1Salvia Miltiorrhiza and Ligustrazine Hydrochloride Injection by caudal vein,respectively. The urine and bile were collected at 0- 4,4- 8,8- 12,12- 24 h and 0- 2,2- 4,4- 6,6- 12,12- 24 h,respectively. The concentrations of ligustrazine hydrochloride in urine and bile were measured by HPLC. Results After intravenous injection different doses of Salviae Miltiorrhiza and Ligustrazine Hydrochloride Injection in rats,few ligustrazine hydrochloride was excreted in urine and bile as prototype. Conclusion The results indicate that prototype was not the main elimination form of ligustrazine hydrochloride in rats.