摘要
目的评价万古霉素在儿科患者中的使用情况及特点,促进临床合理用药。方法通过回顾性分析静脉用万古霉素的住院患儿,提取患儿的病原学检查、疾病情况、药物治疗监测情况、用药时间、疗效等数据进行统计分析。结果 2013年,94例次患儿病例中,经验治疗比例为65.96%;有效率为78.72%;用药原因中肺部感染所占比例最高34.86%;微生物及药敏送检率为96.81%,阳性结果中葡萄球菌占20.81%(36/173);治疗药物监测比例为17.02%。结论临床用万古霉素以经验用药为多,使用基本合理,但用药及监测细节上仍存在一些问题。
Objective To investigate the use of vancomycin in pediatric patients and promote the rational use of vancomycin. Methods By retrospective analysis,data were extracted from medical records of 94 pediatric patients in terms of etiology check,diseases,therapeutic drug monitoring（ TDM）, medication duration, therapeutic efficacy, etc.Results The treatment of vancomycin in 65. 96% was based on experience and the effective rate is 78. 72%. The biggest reason to use vancomycin is pulmonary infection 34. 86%. 96. 81% of the patients completed etiology check and drug sensitive test,and staphylococcal infection accounts for 20. 81%（ 36 /173） of the positive results. 17. 02% of the patients completed therapeutic drug monitoring. Conclusion The treatment of vancomycin is mainly based on experience. Most of the usage is rational,but some details in the usage and TDM should be paid attention.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2014年第9期816-818,共3页
The Chinese Journal of Clinical Pharmacology
基金
北京大学第一医院科研基金资助项目
关键词
万古霉素
儿科患者
合理用药
肺部感染
vancomycin
pediatric patients
drug rational use
pulmonary infection
