肝细胞生长因子逆转心肌肥厚作用的研究进展被引量：1

Research progress of hepatocyte growth factor reverse myocardial hypertrophy function

导出

摘要心肌肥厚是许多心脏疾病共有的病理表现,严重将导致心力衰竭。肝细胞生长因子(HGF)是多功能的细胞因子,近些年研究表明HGF在防治心血管疾病中有重要作用。本文着眼于HGF在心血管系统中发挥作用的分子机制和信号通路,总结现有的关于HGF与心肌肥厚的相关研究,分析HGF对治疗心肌肥大的潜在作用或可能的不利影响。 Cardiac hypertrophy is a common phenomenon in heart diseases,ultimately lead to heart failure. Hepatocyte growth factor（ HGF）,which is a pleiotropic cytokine. It has been considered as a promising candidate for cardiovascular therapy for several years. This review focus on these molecular mechanisms and signaling pathways of HGF targeted in cardiovascular system,and summarizes current research about HGF on cardiac hypertrophy,analyses the potential contribution or adverse effect of HGF on cardiac hypertrophy turns out in different heart diseases.

作者董丽萍蒋园曾凯耿帅佘砚云龚冬梅

机构地区哈尔滨医科大学药理教研室

出处《中国临床药理学杂志》 CAS CSCD 北大核心 2014年第9期868-870,共3页 The Chinese Journal of Clinical Pharmacology

基金国家自然科学基金项目资助(81202523) 黑龙江省高校战略后备人才出国研修基金资助项目

关键词心肌肥厚肝细胞生长因子抗凋亡抗纤维化 cardiac hypertrophy hepatocyte growth factor anti-apoptosis anti-fibrosis

分类号 R541 [医药卫生—心血管疾病] R972 [医药卫生—药品]

引文网络
相关文献

参考文献20

1Taegtmeyer H, Sen S, Vela D. Return to the fetal gene program:a suggested metabolic link to gene expression in the heart[ J]. Ann N Y Acad Sci,2010,1188 : 191 - 198.
2Boccaccio C, Comoglio PM. Invasive growth : A met - driven genetic programme for cancer and stem cells[ J ]. Nat Rev Cancer,2006,6 : 637 - 645.
3Nakamura T, Sakai K, Nakamura T, et al. Hepatocyte growth fac- tor twenty years on:Much more than a growth factor[J]. J Gastroen- terol Hepatol,2011,26( Suppl. 1 ) : S188 - S202.
4Leo C, Sala V, Morello M, et al. Activated met signalling in the developing mouse heart leads to cardiac disease[ J ]. PLoS ONE, 2011,6 : e14675.
5Schroder K, SchUtz S, Schloffel I, et al. Hepatocyte growth factor induces a proangiogenic phenotype and mobilizes endothelial progen- itor cells by activating Nox2 [ J ]. Antioxid Redox Signal,2011,15 : 915 -923.
6Sulpice E, Ding S, Muscatelli - Groux B, et al . Cross - talk be- tween the VEGF- A and HGF signalling pathways in endothelial cells[J]. Biol Cell,2009,101:525 -539.
7Sanada F, Taniyama Y, lekushi K, et al. Negative action of hepa- tocyte growth factor/c - Met system on angiotensin II signaling via ligand - dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells [ J ]. Circ Res, 2009, 105:667 - 675.
8Kaga T, Kawano H, Sakaguchi M, et al. Hepatocyte growth factor stimulated angiogenesis without inflammation:differential actions be- tween hepatoeyte growth factor, vascular endothelial growth factor and basic fibroblast growth factor[J]. Vascul Pharmacol,2012,57: 3-9.
9Silvagno F, Follenzi A, Arese M, et al. In vivo activation of met tyrosine kinase by heterodimeric hepatocyte growth factor molecule promotes angiogenesis[ J]. Arterioscler Thromb Vasc Biol, 1995,15 : 1857 - 1865.
10Banquet S, Gomez E, Nicol L, et al. Artefiogenic therapy by in- tramyocardial sustained delivery of a novel growth factor combination prevents chronic heart failure [ J ]. Circulation, 2011,124 : 1059 - 69.