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药物基因组学与哮喘个体化给药研究进展 被引量：21

Pharmacogenomics and the research progress of personalized medication in asthma
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摘要 治疗哮喘的主要药物包括β2-肾上腺素受体激动剂、糖皮质激素和白三烯调节剂。患者对哮喘药物的反应存在个体差异,这种差异与哮喘相关基因有关。基因某些位点的突变,影响患者对药物的反应性,这些基因包括β2-肾上腺素受体基因(ADRB2)、糖皮质激素受体基因(NR3C1)及白三烯合成酶(LTC4S和ALOX5)基因等。本文对哮喘相关的药物基因组学研究进行综述,希望为哮喘的个体化治疗提供帮助。 The main drugs used for asthma include β2- adrenoceptor agonists,corticosteroids and leukotriene modifiers. Clinical and experimental studies found that there are individual differences in patient＇ s response to asthma drugs. The individual differences is associated with asthma- related genes,while some mutant gene loci can affect the patient＇s response to drug. These genes include β2- adrenergic receptor gene（ ADRB2）,the glucocorticoid receptor gene（ NR3C1）,leukotriene synthase（ LTC4 S and ALOX5） genes and so on. The article will summarize asthma- related pharmacogenomics research,hoping to provide help for the future realization of personalized medicine for asthma.
作者 雷雪春 朱黎明 戴爱国
机构地区 南华大学附属省马王堆医院呼吸疾病研究所
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2014年第9期871-874,共4页 The Chinese Journal of Clinical Pharmacology
基金 国家自然科学基金资助项目(81270093) 湖南省自然科学基金资助项目(12JJ3111) 湖南省科技厅科技计划基金资助项目(2012FJ3075) 湖南省医药卫生科研计划基金资助项目(B2013064)
关键词 哮喘 药物基因组学 β2-肾上腺素受体激动剂 糖皮质激素 白三烯调节剂 asthma pharmacogenomics β2-adrenergic receptor agonist glucocorticoids leukotriene modifer
分类号 R562.25 [医药卫生—呼吸系统] R974.3 [医药卫生—药品]
  • 相关文献

参考文献35

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二级参考文献35

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共引文献12

同被引文献123

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引证文献21

二级引证文献91

中国临床药理学杂志
2014年 第9期

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