功能化石墨烯负载氯霉素稳定性的研究

Functionalized graphene oxide as a nanocarrier for loading of chloramphenicol

目的通过利用β-环糊精对氧化石墨烯进行功能化改性,合成GO-β-CD杂化复合材料,探索其作为新型纳米载体负载药物的应用。方法采用透射电子显微镜(TEM)、扫描电子显微镜(SEM)、拉曼光谱仪、傅立叶变换红外检测器(FT-IR)等检测方法对GO-β-CD的形貌和结构进行表征。结果利用GO-β-CD体系对氯霉素进行负载,载药量高达115%,氯霉素滴眼液加速实验90d后,测得二醇物含量分别为10.13%(市售处方)和7.28%(改进处方)(≤8.0%,符合药典)。结论通过功能化的石墨烯载体对药物进行负载后,氯霉素的稳定性显著提高,并提高了制剂质量。

Objective In order to explore grapheme oxide （GO） as a new nano carrier-supported drug, β-cyclodextrin was grafted on to grapheme oxide via an esterification process to synthetic GO-β-CD hybrid composite materials. Methods The morphology and structure of the material was characterized by transmission electron microscopy （TEM）, scanning electron microscopy （SEM）, Raman spectroscopy, Fourier transform infrared detector （FT-IR） and other detection methods. Results The drug loading ratio was determined to be as high as 115% with using of GO-β-CD system as a nanocarrier for loading of chloramphenicol, which after 90 days of chloramphenicol eye drops accelerated test, and the measured glycol extracts were 10.13% （commercially available prescription） and 7.28% （improved prescription） （≤8.0%, Pharmacopoeia standard）. Conclusion The stability ofchloramphenicol by functionalized GO and the quality of the preparation was significantly increased.