中国肥胖儿童FTO基因多态性与肥胖儿童代谢组分关联研究

FTO polymorphisms associated with metabolic components in Chinese obese children

目的研究FTO基因多态性与肥胖儿童代谢组分相关性。方法选择年龄6~17岁间的599名儿童,检测FTO基因常见的单核苷酸多态性(rs1421085、rs17817449、rs8050136、rs3751812和rs9939609)基因型,分析与肥胖代谢组分的关联性。结果 1肥胖儿童代谢组分与对照组有显著差异;2FTO SNPs的等位基因频率与基因型分布存在显著差异。5个FTO SNP突变型是儿童发生肥胖的危险因素;3多变量、Logistic回归分析发现5个FTO单核苷酸多态性均与高收缩压有关。rs3751812、rs8050136与LDL-C、HOMA-IR相关。结论 FTO基因SNPs与儿童肥胖和高血压有关。rs3751812和rs8050136与胰岛素抵抗及血清LDL水平升高有关。

Objective To investigate whether FrO gene SNP polymorphisms were associated with metabolic traits in Chinese children. Methods A total of 595 children aged between 6 and 17 years were enrolled. The five common SNPs in the Fro gene（rs1421085, rs17817449, rs8050136, rs3751812 and rs9939609 ） were genotyped. Metabolic compo- nents and insulin were measured. Results （1）The obese patients showed the components of the metabolic traits were significant difference compared to control group. （2）The allele frequency and the genotype distribution of the five SNPs were significant differences between two groups. Minor allele carriers of the five SNPs were associated with increased risks of childhood obesity compared with the wild-type genotype. （3）After adjustment of age, sex and BMI-z score, all of the five SNPs showed a trend towards higt^er SBP. In addition, rs3751812 and rs8050136 showed significant as- sociation with LDL-C and HOMA-IR levels. Conclusion The five common SNPs in the FTO gene contributes to the e- tiology of obesity and hypertension. The FTO gene polymorphisms （rs3751812 and rs8050136） are found to be associ- ated wifh increased insulin resistance and plasma LDL levels.