齐拉西酮与利培酮治疗精神分裂症的疗效对比研究

Comparative study of the efficacy of ziprasidone and risperidone in the treatment of schizophrenia

目的 对比齐拉西酮与利培酮治疗精神分裂症的疗效。方法 选择我院2010年1月～2014年1月期间住院治疗的精神分裂症患者60例作为观察对象,60例精神分裂症患者随机分为A组（齐拉西酮）与B组（利培酮）,每组30例,比较两组患者治疗前后PANSS评分变化及两组患者治疗后的疗效、不良反应。结果 治疗第4、8周末,A组与B组患者的PANSS总分、PANSS阳性症状分、PANSS阴性症状分均较治疗前明显降低（P〈0.05）。且A组治疗第4、8周末PANSS评分显著低于B组,差异有统计学意义（P〈0.05）,但A组与B组治疗第4、8周末患者的PANSS阳性症状分、PANSS阴性症状分组间比较差异不显著。A组的总有效率达86.7%,虽然高于B组的总有效率83.3%,但组间比较差异无统计学意义（P〉0.05）。A组治疗6周末不良反应发生率达20%,B组不良反应的发生率达40%,A组的不良反应发生率明显低于B组,差异有统计学意义（P〈0.05）。结论 齐拉西酮与利培酮治疗精神分裂症均具有较好的疗效,但齐拉西酮较利培酮更具优势,不良反应少。

Objective To compare the efficacy of zillah risperidone and risperidone in the treatment of schizophrenia. Methods In our hospital from January 2010 to January 2014,selected 60 cases schizophrenic patients hospitalized as observed object,60 cases hospitalized patients with schizophrenia during as the observed object, all patients were ran- domly divided into group A （ziprasidone） and group B （risperidone）, each group of 30 patients, before and after treatment efficacy PANSS score changes and two groups of patients after treatment, adverse reactions were compared between two groups. Results After 4,8 weeks, the PANSS total score,PANSS positive symptoms, PANSS negative symptoms of A group and B group were significantly lower than before treatment, the difference was statistically signifi- cant （P〈O.05）,PANSS scores of A group after treatment 4,8 weeks were significantly lower than in group B,the differ- ence was statistically significant （p〈0.05）, but after treatment 4,8 weeks,PANSS positive symptoms, PANSS negative symptoms of group A and group B had no significant significance. The total effective rate of A group was 86.7% ,was higher than that in group B （83.3%） ,but the difference was not statistically significant between the two groups （P〉 0.05）. After treatment for 6 weeks,the incidence of adverse reactions of A group was 20%, group B was 40%, the inci- dence of adverse reactions in group A was significantly lower than group B,the difference was statistically significant （P〈O.05）. Conclusion Ziprasidone and risperidone in the treatment of schizophrenia have better efficacy, but com- pared to risperidone, ziprasidone has advantages, with fewer adverse reactions.