综合性健康教育对还原型谷胱甘肽联合二甲双胍治疗非酒精性脂肪肝疗效的影响

The effects of comprehensive health education for glutathione combined with metformin in treatment of nonalcoholic fatty liver

目的 探讨综合性健康教育对还原型谷胱甘肽联合二甲双胍治疗非酒精性脂肪肝疗效的影响。方法 选择2012年1月~2014年1月我院收治的非酒精性脂肪肝患者64例,随机分为干预组和对照组,两组均予还原型谷胱甘肽片,每次1片,3次/d;二甲双胍片每次1片,3次/d。疗程6个月,对照组实施对症护理,干预组实施综合性健康教育,比较两组治疗后的疗效及两组患者治疗前后ALT、AST、TC、TG、BMI水平变化情况及两组患者治疗后体重指数〉23 kg/m2的异常率、腰围≥80cm异常率、血脂异常率、肝功能异常率、超声结果异常率。结果 干预组治疗后总有效率达93.8%,显著高于对照组的71.9%,差异有统计学意义（P〈0.05）。治疗后,干预组患者的ALT、AST、TC、TG、BMI水平均较治疗前显著降低,且干预组患者的ALT、AST、TC、TG、BMI水平均明显低于对照组,差异有统计学意义（P〈0.05）。干预组患者体重指数〉23kg/m2的异常率、腰围≥80cm异常率、血脂异常率、肝功能异常率、超声结果异常率明显低于对照组,差异有统计学意义（P〈0.05）。结论 综合性健康教育可提高还原型谷胱甘肽联合二甲双胍治疗非酒精性脂肪肝的疗效,改善临床症状、降低血脂及改善肝功能,值得推广和应用。

Objective To investigate the effects of comprehensive health education for glutathione combined with met- formin in treatment of nonalcoholic fatty liver. Methods A total of 64 patients with nonalcoholic fatty liver from Jan- uary 2012 to January 2014 in our hospital, two groups were treated glutathione tablets, one tablet each time, 3 times every day; metformin tablets, one tablet each time, 3 times every day. The total courses were six months. All patients were randomly divided into intervention group and control group, the control group took random symptomatic care, the intervention group implemented a comprehensive health education interventions, the efficacy and the two groups of pa- tients after treatment ALT,AST, TC, TG, BMI levels, and BMI〉 23kg/m2 abnormal rate, the rate of abnormal waist cir- cumference ≥ 80 cm, dyslipidemia, abnormal liver function rate, rate of abnormal ultrasound findings were compared between two groups. Results After treatment, the effective rate of the intervention group was 93.8%, was significantly higher than the control group 71.9%, the difference was statistically significant （P 〈0.05）. After treatment, the ALT, AST, TC, TG, BMI levels of the intervention group were significantly lower than before treatment, and the ALT, AST, TC, TG, BMI of intervention group was significantly lower than the control group （P 〈0.05）. BMI〉23 kg/m2 abnormal rate, waist circumference≥80 cm abnormal rate, dyslipidemia, abnormal liver function rate, abnormal ultrasound results of intervention group were significantly lower than the control group,the difference was significant（P 〈0.05）. Conclusion The comprehensive sexual health education can improve the effect of glutathione combined with metformin therapy in patients with non-alcoholic fatty liver, improve clinical symptoms, reduce blood fat and improve liver function, worthy of promotion and application.