温阳补肾祛瘀化痰法治疗阿茨海默病临床研究

Therapeutic Effect of Therapy of Warming Yang and Tonifying Kidney, Removing Blood Stasis and Phlegm for Alzheimer's Disease

目的:观察温阳补肾祛瘀化痰法治疗阿茨海默病(AD)的临床疗效。方法:选择AD患者80例,随机分为治疗组及对照组,每组各40例。治疗组服用中药温阳补肾祛瘀化痰法中药,对照组口服尼莫地平、盐酸多奈哌齐片,治疗3月。2组分别在治疗前后进行简易智能状态检查修正表(MMSE)和日常生活能力量表(ADL)评分。结果:治疗组显效10例,有效19例,无效11例,总有效率72.5%;对照组显效8例,有效13例,无效19例,总有效率52.5%。2组比较,治疗组总有效率优于对照组(P<0.05)。2组治疗后MMSE和ADL评分均高于治疗前(P<0.05),且治疗组高于对照组,差异有显著性意义(P<0.05)。结论:温阳补肾祛瘀化痰法治疗AD疗效确切。

Objective. To observe the clinical curative effect of the therapy of warming yang and tonifying kidney, removing blood stasis and phlegm for Alzheimer＇s disease（AD）. Methods： Eighty cases of Alzheimer＇s disease were randomly divided into treatment group and control group, 40 cases in each group. The treatment group was given the decoction of Chinese medicine with the actions of warming yang and tonifying kidney, removing blood stasis and phlegm, and the control group was treated with Nimodipine and Donepezil hydrochloride. The treatment course lasted for 3 months. Mini-Mental State Examination（MMSE） and Activity of Daily Living Scale（ADL） scores were observed in both groups before and after treatment. Results： The total effective rate was 72.5% in the treatment group, and was 52.5% in the control group, the difference being significant（P〈 0.05）. The scores of MMSE and ADL were increased after treatment（P〈 0.05 compared with those before treatment）, and the scores of the treatment group were higher than those of the control group（P〈 0.05）. Conclusion. Chinese medicine of warming yang and tonifying kidney, removing blood stasis and phlegm shows certain curative effect for Alzheimer＇s disease.