胸腺五肽辅助治疗多耐药肺结核患者的临床研究

Effect of thymopentin on patients with multi-drug-resistant tuberculosis

目的分析胸腺五肽辅助治疗多耐药肺结核患者的临床疗效。方法选择在该院接受治疗的58例多耐药肺结核患者作为研究对象,随机分为观察组和对照组,各29例。对照组患者接受常规化疗方案,观察组在此基础上加用胸腺五肽辅助治疗。比较两组患者的治疗前后肺功能、免疫功能指标及痰菌转阴率等情况差异。结果观察组患者接受胸腺五肽辅助治疗后的FEV1、FVC和FEV1/FVC值均高于对照组患者(P<0.05)。同时观察组患者各项免疫功能指标值也明显高于对照组(P<0.05)。观察组患者治疗后各个时间点的痰菌转阴率均显著高于对照组(P<0.05)。结论胸腺五肽辅助治疗可以提高多耐药肺结核患者的肺功能、增强免疫功能,并且促进痰菌转阴。

【Objective】To analyze the effect of thymopentin on patients with multi-drug-resistant tuberculosis.【Methods】The patients with multi-drug-resistant tuberculosis in our hospital were randomly divided into control groups receiving conventional chemotherapy and observation group accepting thymopentin adjuvant therapy, lung function, immune function and sputum negative rates were compared. 【Results】The value of FEV1, FVC, FEV1/FVC in observation group after the thymopentin treatment were higher than that in control group（P〈0.05）. The immune function in observation group were significantly better than that in control group（P〈0.05）. The sputum negative conversion rate in patients with observation group in each time point were significantly higher than that in control group（P〈0.05）.【Conclusion】Thymopentin adjuvant therapycan optimize multi-drug-resistant tuberculosis in patients with pulmonary function, enhance immune function and promote sputum negative.