摘要
转化生长因子-β（TGF-β）是一种多功能蛋白,具有调节细胞增殖、分化、迁移及凋亡等多种细胞生物学效应.已有研究证实,TGF-β是重要的促纤维化细胞因子之一,且与肿瘤的发展密切相关.Smad信号是其发挥作用的主要通路.而近年研究发现,E3泛素连接酶Arkadia通过Smad信号能起到增强TGF-β信号通路生物学效应的作用,因而日益引起人们的关注.拟对TGF-β信号转导通路中Arkadia的作用作一综述.
Transforming growth factor-β （TGF-β） is a multifunctional protein and regulates a wide variety of cellular bio-effects,such as proliferation,differentiation,migration and apoptosis.Studies have proven that TGF-β is one of the important cytokines that promote fibrosis,and it is confirmed to be closely related to the progression of tumor.Smad signaling is the major pathway in which TGF-β fulfills its functions.These years,it has been found that E3 ubiquitin ligases Arkadia can enhance the biological effect of TGF-β signal transduction pathway through Smad signaling pathway.Therefore,it is increasingly attracting public attention.This study will summarize the effects of Arkadia on TGF-β/Smad signal transduction pathway.
出处
《国际生物医学工程杂志》
CAS
2014年第4期251-254,I0006,共5页
International Journal of Biomedical Engineering
基金
国家自然科学基金青年科学基金资助项目（81300314）
中国肝炎基金会-王宝恩肝纤维化基金资助项目（CFHPC20120145）
关键词
Arkadia
TGF-Β信号通路
SMAD
Arkadia
TGF-β signal transduction pathway
Drosophila mothers against decapentaplegic
