中老年人群25-羟维生素D3与代谢综合征的相关性分析

Association between 25-hydroxyvitamin D3 and metabolic syndrome in middle-aged and elderly population

目的 研究中老年人群25-羟维生素D3[25 （OH） D3]与代谢综合征（MS）及其各组分的关系.方法 采用整群随机抽样方法选取贵阳市宅吉小区50 ～70岁,且在本社区居住10年以上人群463名,男性190名,女性273名.所有研究对象进行问卷调查,测量身高、体重、腰围、血压等相关指标,抽血测血糖、血脂、空腹胰岛素、25（OH）D3浓度等指标.MS的诊断采用国际糖尿病联盟标准.结果 （1）血清25 （OH） D3水平为（21.98±8.32） ng/ml,MS的患病率为38.9％,MS在25 （OH） D3异常及正常组人群的患病率依次为82.8％、26.6％（P均＜0.05）.（2）25（OH） D3正常组男性比例、教育程度、钙剂补充高于25 （OH） D3异常组;腰围、空腹血糖、口服葡萄糖耐量试验2h血糖、甘油三酯及稳态模型评估-胰岛素抵抗指数（HOMA-IR）低于25 （OH） D3异常组（P＜0.05）.（3）25（OH）D3水平与MS的发生呈负相关[β=-0.667,优势比（OR）=0.513,P＜0.05];与腰围、空腹血糖、甘油三酯、HOMA-IR呈负相关（P＜0.05）.结论 中老年人群低25（OH）D3水平更易发生MS,低25 （OH） D3水平可能增加MS及其各组分的患病风险.

Objective To evaluate the association between 25-hydroxyvitamin D3 [25 （OH） D3] and metabolic syndrome（MS） as well as the components of MS in middle-aged and elderly population.Methods A total of 463 individuals （190 male cases and 273 female cases） aged 50-70 years with more than 10 years of residence in Zhaiji community of Guiyang city were recruited by cluster random sampling method.A standard questionnaires,anthropometric parameters,blood lipids,blood glucose,fasting insulin,plasma 25 （OH）D3 concentration were tested.MS was diagnosed according to the International Diabetes Federation （IDF） criteria.Results （1） The mean25（OH）D3 concentration was （21.98＆#177;8.32） ng/ml.Prevalence of MS was 38.9 %.In 25 （OH） D3 deficiency,insufficiency,and sufficiency group,the prevalence of MS were 82.8%,and 26.6% （P 〈 0.05）.（2） Compared with 25 （OH） D3 abnormal group,the male percentage,education and calcium supplement in 25 （OH） D3 sufficiency group were higher（P 〈 0.05） and waist circumference,fasting plasma glucose,oral glucose tolerance test 2 hours glucose,triglyceride,homeostasis model of assessment for insulin resistance index （HOMA-IR）was lower （P 〈0.05）.（3）An inverse associations existed between 25 （OH） D3 levels and MS prevalence [β =-0.667,odd ratio （OR） =0.513,P 〈 0.05].Plasma 25 （OH）D3 concentration was significantly and negatively associatied with waist circumference,fasting plasma glucose,triglyceride and HOMA-IR （P 〈 0.05）.Conclusions Middle-aged and elderly people with lower 25 （OH）D3 level has higher MS prevalence.A low 25 （OH）D3 level may increase the risk of MS and components of MS.