摘要
炎性反应在糖尿病肾病（DN）的发生、发展中起重要作用.高糖作为始动因素,与晚期糖基化终末产物（AGEs）、氧化应激及肾内血流动力学的改变共同引起了糖尿病肾脏炎性反应的发生.而二甲双胍作为治疗糖尿病的一线药物,近年研究显示其除降糖作用以外,还可通过激活腺苷酸活化蛋白激酶（AMPK）、抗氧化应激和改善胰岛素抵抗等机制发挥抗炎作用,从而预防和延缓DN的发生和发展.
Inflammation plays an important role in the occurrence and development of diabetic nephropathy （DN）.Hyperglycemia as the initiating factor,combined with advanced glycosylation end products （AGEs）,oxidative stress and the renal hemodynamic changes causes a inflammation in diabetic renal tissue.Except the hypoglycemic effect,metformin,as the first-line drugs for the treatment of diabetes,can prevent and delay the occurrence and progress of DN through some anti-inflammatory mechanisms,which include activation of the AMP activated protein kinase （AMPK）,anti-oxidative stress and improvement of insulin resistance.
出处
《国际内分泌代谢杂志》
北大核心
2014年第5期334-336,共3页
International Journal of Endocrinology and Metabolism
关键词
二甲双胍
糖尿病肾病
炎症
氧化应激
Metformin
Diabetic nephropathy
Inflammation
Oxidative stress
