奥曲肽与垂体后叶素治疗肝硬化上消化道出血的临床效果比较

Comparision of clinical effect of octreotide and pituitrin in treatment of liver cirrhosis complicated with upper digestive tract hemorrhage

目的：比较奥曲肽与垂体后叶素治疗肝硬化并发上消化道出血的临床效果。方法将本院2011年5月～2013年12月收治的76例肝硬化并发上消化道出血患者分成治疗组39例和对照组37例。对照组给予常规治疗加垂体后叶素治疗，治疗组给予常规治疗联合奥曲肽治疗，连续使用7d，比较两组的临床疗效和不良反应。结果治疗组的总有效率为94.9%，对照组为64.9%，两组比较，差异有统计学意义（P〈0.01）。治疗组出现呕吐2例、腹痛2例，不良反应发生率为10.2%，对照组出现呕吐3例，恶心1例，腹痛4例，高血压4例，头痛2例，不良反应发生率为37.8%，两组比较，差异有统计学意义（P=0.005）。结论奥曲肽治疗肝硬化并发上消化道出血的临床效果优于垂体后叶素，不良反应少，可在临床推广。

Objective To compare the clinical effect of octreotide and pituitrin in treatment of liver cirrhosis complicated with upper digestive tract hemorrhage. Methods 76 patients with liver cirrhosis complicated with upper digestive tract hemorrhage treated in our hospital from May 2011 to December 2013 were divided into the treatment group （n=39） and control group （n=37）.The control group was given conventional therapy plusing pituitrin,the treatment group was given conventional treatment combined with octreotide,drugs were used continuously for 7 days.Clinical curative effect and adverse reaction of the two groups were compared. Results The total effective rate of the treatment group was 94.9%,and it was 64.9% in the control group,and there was a statistical difference of the two groups （P〈0.01）.There were 2 cases with vomiting,2 cases with abdominal pain,the incidence rate of adverse reaction was 10.2%,and there were 3 cases with vomiting,1 case with nausea,4 cases with abdominal pain,2 cases with headache,4 cases with hyper-tension,the incidence rate of adverse reaction was 37.8%,and there was a statistical difference of the incidence rate of adverse reaction in the two groups （P=0.005）. Conclusion The clinical effect of octreotide treating liver cirrhosis complicated with upper digestive tract hemorrhage is better than pituitrin with less adverse reaction,and it can be popularized in clinic.