哺乳动物生物钟与能量代谢的相关研究进展

Advances on the relationship between circadian clock and metabolism in mammals

生物钟广泛存在于各种生物体中,是生命体的一种内源调节机制。哺乳动物生物钟系统与机体营养代谢和能量平衡有着密切的关系。概述了生物钟系统通过营养途径、限速酶途径、核受体途径对哺乳动物机体代谢活动和能量平衡的调控,以及哺乳动物代谢稳态对生物钟系统的影响,从而为从生物钟调控的角度治疗和防控代谢综合征提供新的思路。

Circadian clock is an endogenous regulating mechanism involved in almost all eukaryotes. Recent evidence has shown close relationship among the mammalian circadian system, energy balance, and nutrient metabolism. This article briefly reviews the function of mammalian circadian system in regulating nutrient metabolism and energy homeostasis by the nutrient sensors, rate-limiting enzymes, and/or the nuclear receptors. Moreover, the role of mammalian metabolism homeostasis in circadian regulation is also stated. These findings may provide new ideas in the prevention and treatment of metabolic syndromes.