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碱基切除修复在阿尔茨海默病和帕金森病中的作用

The roles of base excision repair in Alzheimer's disease and Parkinson's disease
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摘要 细胞代谢或细胞应激均可以引起DNA氧化损伤。DNA氧化损伤与神经退行性疾病的发生、发展密切相关。碱基切除修复在抵抗脑细胞DNA氧化损伤中起着重要的作用。就碱基切除修复在阿尔茨海默病(Alzheimer’s disease,AD)和帕金森病(Parkinson’s disease,PD)中的作用及其机制进行综述。 Oxidative DNA damage can be induced by cellular metabolism and cellular stress. Oxidative DNA damage is implicated in neurodegenerative diseases. The base excision repair plays an important role in repairing oxidative DNA damage. This paper reviews the roles of base excision repair in Alzheimer＇s disease and Parkinson＇s disease and its mechanisms.
作者 贾金婧 曾宪思 白洁
机构地区 昆明理工大学环境科学与工程学院 昆明王旱T大学瞑举院.昆明
出处 《生命科学》 CSCD 2014年第9期962-966,共5页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金项目(81160162,U120 2227) 昆明理工大学医学神经生物学重点实验室项目(14078142)和创新团队
关键词 DNA氧化损伤 碱基切除修复 阿尔茨海默病 帕金森病 oxidative DNA damage base excision repair Alzheimer＇s disease Parkinson＇s disease
分类号 Q7 [生物学—分子生物学] R749.16 [医药卫生—神经病学与精神病学]
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生命科学
2014年 第9期

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