慢性非糖尿病肾病患者血清胱抑素C的检测及临床分析

Clinical analysis and detection of serum cystatin C in clinical diagnosis of patients with chronic non-diabetic kidney disease

目的探讨血清胱抑素C（CysC）在慢性非糖尿病肾病2～4期患者中的水平及与其他肾功能评价指标的相关性。方法对129例慢性非糖尿病肾病患者和35例健康体检者（对照组）进行CysC和其他肾功能指标检测。结果慢性非糖尿病肾病2～4期患者的估计肾小球滤过率（eGFR）、肌酐（SCr）、C反应蛋白、尿素氮和CysC指标与对照组相比,差异均有统计学意义（P〈0.05）。与对照组相比,慢性肾病2～4期患者的红细胞压积、纤维蛋白原的差异有统计学意义（P〈0.05）。直线相关回归分析显示,CysC与SCr呈显著正相关（r=0.802,P〈0.01）;CysC与尿素氮呈显著正相关（r=0.796,P〈0.01）;CysC与eGFR呈显著负相关（r=-0.812,P〈0.01）。慢性肾病不同分期患者中,随着eGFR的减少,CysC水平逐渐增加。结论血清CysC检测是评估慢性肾病患者肾小球滤过功能较理想的指标。

Objective To study the role of serum cystatin C in clinical diagnosis of patients with stage 2-4 chronic non-diabetic kidney disease. Methods Serum cystatin C and other kidney functional indexes were analyzed in 129 patients with chronic non-diabetic kidney disease and 35 controls admitted to Beijing You＇an hospital. Results There were statistically significant differences between the group of patients with stage 2-4 chronic non-diabetic kidney disease and the control with the eGFR, SCr, BUN and cystatin C（P〈0.05）. There were statistically significant differences with hematocrit and fibrinogen between the group of patients with stage 2-4 chronic non-diabetic kidney disease and the control（P〈0.05）. On linear regression, the cystatin C was found to be directly correlated to SCr（r = 0.802, P〈0.01）and BUN（r =0.796,P〈0.01）. The cystatin C was found to be inverse correlated to eGFR（r =-0.812, P〈0.01）. The cystatin C concentration progressively increased while eGFR was decreasing in these patients. Conclusion Cystatin C is a sensitive indicator in judgement of renal damage of chronic non-diabetic kidney disease and assessment of GFR.