新生儿窒息亚低温治疗后脑干听觉诱发电位变化分析

Analysis on the change of brainstem auditory evoked potential after mild hypothermia treatment in neonates with asphyxia

目的：探讨新生儿窒息亚低温治疗后脑干听觉诱发电位变化。方法：将符合亚低温入选条件72例窒息新生儿,随机分成亚低温组36例、常规治疗组36例,同期正常产足月儿32例为对照组,亚低温组入院后即行亚低温联合三支持三对症治疗,常规治疗组给予三支持三对症治疗,分别于治疗后（日龄6-7天）及1月（4-5周）行脑干听觉诱发电位检查。结果：亚低温治疗可降低脑干听觉诱发电位检查中Ⅰ、Ⅲ、Ⅴ波的平均潜伏期、缩短峰间期进行比较,结果有统计学差异（P〈0.05）。结论：对于符合条件的患儿,尽早使用亚低温治疗并行脑干听觉诱发电位检查,提早检出窒息新生儿有无脑功能损伤和听损伤。

Objective： To explore the change of brainstem auditory evoked potential after mild hypothermia treatment in neonates with asphyxia. Methods： A total of 72 neonates with asphyxia meeting the inclusion criteria of mild hypothermia were randomly divided into mild hypothermia group and conventional therapy group, 36 neonates in each group; 32 normal full - term neonates during the same period were selected as control group. The neonates in mild hypothermia group were treated with mild hypothermia combined with support and symp- tomatic treatment after hospital admission, while the neonates in conventional therapy group were treated with support and symptomatic treat- ment; brainstem auditory evoked potential （BAEP） test was performed after treatment （6 -7 days） and at 1 month （4 -5 weeks）, respec- tively. Results： Mild hypothermia treatment could reduce the average incubation periods of Ⅰ, Ⅲ, Ⅴ waves and shorten peak interval dur- ing BAEP test, there were statistically significant differences among the three groups （P 〈 0. 05 ） . Conclusion： For the neonates meeting the inclusion criteria of hypothermia, timely mild hypothermia treatment combined with BAEP test can detect brain injury and hearing loss in neonates with asphyxia.